Input‐output relation of transmission through cuneate nucleus.
Input‐output relation of transmission through cuneate nucleus.
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通过楔形核传输的输入输出关系。
DOI：
10.1113/jphysiol.1976.sp011398
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
M. Morris
中科院分区：
文献类型：
--
作者：
K. Krnjević;M. Morris
1.在去大脑猫中，将微电极插入楔束核，以不同强度的单次电击刺激传入末梢。通过整合前肢皮神经的逆向反应和内侧丘系的顺向反应来估计核的输入和输出。2.输入-输出曲线通常是非常非线性的，反映了小输入的高突触效能。它们很容易用幂函数拟合，指数平均值为0 - 50。3.正常的输入输出关系在血液供应中断后迅速消失。指数大于或等于1的曲线表明小输入突触效率的损失，这与末端兴奋性的急剧增加有关。4.在表面温度30 - 40摄氏度的范围内，变暖使输入-输出曲线变陡，但降低了终端兴奋性，而冷却则有相反的效果。因此，传输效率与终端兴奋性呈负相关。5.电流输入-输出曲线的非线性形状可能不是由抑制控制决定的，因为印防己毒素抑制而不是增强输出。6.另一方面，戊巴比妥使输入-输出曲线明显变陡，并倾向于降低终末兴奋性。
1. In decerebrate cats, micro‐electrodes were inserted into the cuneate nucleus to stimulate afferent terminals with single shocks of varying intensities. Estimates of the input and output of the nucleus were obtained by integrating antidromic responses in forelimb cutaneous nerves and orthodromic responses in the medial lemniscus. 2. Input‐output curves were normally very non‐linear, reflecting the high synaptic potency of small inputs. They were fitted readily by power functions, with exponents averaging 0‐50. 3. The normal input‐output relation rapidly disappeared after interruption of the blood supply. A loss of synaptic efficiency of small inputs was indicated by curves with exponents of greater than or equal to 1; this was associated with a sharp increase in terminal excitability. 4. Within the range of surface temperature 30‐40 degrees C, warming made the input‐output curves steeper but reduced terminal excitability, whereas cooling had the opposite effect. The efficiency of transmission was thus inversely correlated with terminal excitability. 5. The non‐linear shape of cuneate input‐output curves is probably not determined by inhibitory control, since picrotoxin depressed rather than enhanced outputs. 6. On the other hand, pentobarbitone made the input‐output curves markedly steeper and tended to lower terminal excitability.