Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.
Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1161/jaha.113.000506
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发表时间：
2013-12-18
影响因子：
5.4
通讯作者：
Mozaffarian D
中科院分区：
文献类型：
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作者：
de Oliveira Otto MC;Wu JH;Baylin A;Vaidya D;Rich SS;Tsai MY;Jacobs DR Jr;Mozaffarian D
膳食指南支持摄入鱼油和植物油中的多不饱和脂肪酸（PUFA）。然而，关于PUFA的益处仍然存在一些争议，大多数先前的研究都依赖于相对同质人群的自我报告饮食评估。在2837名美国成年人（白人、西班牙裔、非洲裔美国人、华裔美国人）的多种族队列中，使用气相色谱法测量基线（2000-2002年）血浆磷脂PUFA，并使用食物频率问卷估计饮食PUFA。在19778人-年的随访中，前瞻性确定了截至2010年的心血管疾病（CVD）事件（包括冠心病和卒中; n=189）。在多变量校正的考克斯模型中，循环中n-3二十碳五烯酸和二十二碳六烯酸与CVD事件呈负相关，二十碳五烯酸的极端四分位风险比（95% CI）为0.49（0.30至0.79; Ptrend=0.01），二十二碳六烯酸为0.39（0.22至0.67; Ptrend<0.001）。n-3二十二碳五烯酸（DPA）在白人和中国人中与CVD呈负相关，但在其他人种/种族中不相关（P-相互作用=0.01）。未观察到循环n-3 α-亚麻酸或n-6 PUFA（亚油酸、花生四烯酸）与CVD的显著相关性。自我报告的饮食PUFA与CVD的相关性与PUFA生物标志物的相关性一致。除二十二碳五烯酸外，所有相关性在种族-族裔群体中均相似。饮食和循环中的二十碳五烯酸和二十二碳六烯酸，但不是α-亚麻酸或n-6 PUFA，与CVD发病率呈负相关。这些研究结果表明，增加海鲜中n-3 PUFA的摄入量可能会预防多种族人群的CVD发展。
Dietary guidelines support intake of polyunsaturated fatty acids (PUFAs) in fish and vegetable oils. However, some controversy remains about benefits of PUFAs, and most prior studies have relied on self‐reported dietary assessment in relatively homogeneous populations. In a multiethnic cohort of 2837 US adults (whites, Hispanics, African Americans, Chinese Americans), plasma phospholipid PUFAs were measured at baseline (2000–2002) using gas chromatography and dietary PUFAs estimated using a food frequency questionnaire. Incident cardiovascular disease (CVD) events (including coronary heart disease and stroke; n=189) were prospectively identified through 2010 during 19 778 person‐years of follow‐up. In multivariable‐adjusted Cox models, circulating n‐3 eicosapentaenoic acid and docosahexaenoic acid were inversely associated with incident CVD, with extreme‐quartile hazard ratios (95% CIs) of 0.49 for eicosapentaenoic acid (0.30 to 0.79; Ptrend=0.01) and 0.39 for docosahexaenoic acid (0.22 to 0.67; Ptrend<0.001). n‐3 Docosapentaenoic acid (DPA) was inversely associated with CVD in whites and Chinese, but not in other race/ethnicities (P‐interaction=0.01). No significant associations with CVD were observed for circulating n‐3 alpha‐linolenic acid or n‐6 PUFA (linoleic acid, arachidonic acid). Associations with CVD of self‐reported dietary PUFA were consistent with those of the PUFA biomarkers. All associations were similar across racial‐ethnic groups, except those of docosapentaenoic acid. Both dietary and circulating eicosapentaenoic acid and docosahexaenoic acid, but not alpha‐linolenic acid or n‐6 PUFA, were inversely associated with CVD incidence. These findings suggest that increased consumption of n‐3 PUFA from seafood may prevent CVD development in a multiethnic population.