RAPID SEGREGATION OF HETEROPLASMIC BOVINE MITOCHONDRIA
RAPID SEGREGATION OF HETEROPLASMIC BOVINE MITOCHONDRIA
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DOI：
10.1093/nar/17.18.7325
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发表时间：
1989-09-25
影响因子：
14.9
通讯作者：
HAUSWIRTH, WW
中科院分区：
文献类型：
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作者：
ASHLEY, MV;LAIPIS, PJ;HAUSWIRTH, WW
通过跟踪异质性线粒体DNA突变在荷斯坦奶牛四代之间的传播，我们已经证明，在单一哺乳动物世代之间，异质性水平可能发生实质性变化，中性线粒体基因型会在同一雌性后代中以不同方向分离，并且可能只需两到三代就会恢复同质性。哺乳动物线粒体DNA分离的这种明显的快速速度与以前在昆虫中观察到的慢得多的速度形成了对比，这表明在线粒体基因传递机制上，不同类群之间存在根本的差异。
By following the transmission of a heteroplasmic mitochondrial DNA mutation through four generations of Holstein cows, we have documented that substantial shifts in the levels of heteroplasmy can occur between single mammalian generations, that neutral mitochondrial genotypes can segregate in different directions in offspring of the same female, and that a return to homoplasmy may occur in only two or three generations. This apparently rapid rate of mitochondrial DNA segregation in mammals contrasts to the much slower rates observed previously in insects and suggest fundamental differences between taxa regarding the mechanisms of mitochondrial gene transmission.