The mechanism of rapid, shallow breathing after inhaling histamine aerosol in exercising dogs.
The mechanism of rapid, shallow breathing after inhaling histamine aerosol in exercising dogs.
复制标题
运动犬吸入组胺气溶胶后呼吸急促、浅弱的机制。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
J. Nadel
中科院分区：
文献类型：
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作者：
E. Bleecker;D. Cotton;S. Fischer;P. Graf;W. Gold;J. Nadel
在4只未服用镇静剂的运动犬中，我们研究了吸入组胺气雾剂对分通气量、呼吸频率、潮气量、总肺阻力和动态肺顺应性的影响。吸入1 - 2%组胺气溶胶（5次呼吸）通过增加呼吸频率（平均166%，p小于0.001）增加分钟通气量（平均42%，p小于0.0001）。总肺阻力增加（平均200%；P < 0.001）。补充氧气呼吸不影响组胺通气反应。向狗的气道添加外部阻力负荷并不能模拟组胺产生的快速浅呼吸模式。吸入特布他林可阻止总肺阻力和动态肺顺应性的改变，但不能改变组胺的通气反应。当颈部迷走神经（长期植入皮肤回路中）的传导被冷却阻断时，对组胺的通气反应被消除。我们的结论是，组胺通过刺激传入通路在迷走神经中的受体来刺激呼吸；有效刺激不是支气管收缩，而可能是由于气道受体的直接刺激。
In 4 unsedated, exercising dogs, we studied the effects of inhaled histamine aerosol on minute volume of ventilation, respiratory frequency, tidal volume, total pulmonary resistance, and dynamic pulmonary compliance. Inhalation (5 breaths) of 1 to 2 per cent histamine aerosols increased minute ventilation (mean, 50 per cent; p less than 0.001) by increasing respiratory frequency (mean, 166 percent; P less than 0.001), despite decreasing tidal volume (mean, 42 percent; P less than 0.0001). Total pulmonary resistance increased (mean, 200 per cent; P less than 0.001.) Breathing supplemental O2 did not affect the ventilatory response to histamine. Adding external resistive loads to a dog's airway did not simulate the pattern of rapid, shallow breathing produced by histamine. Inhalation of terbutaline prevented the changes in total pulmonary resistance and dynamic pulmonary compliance but did not alter the ventilatory response to histamine. When conduction in the cervical vagus nerves (which were implanted chronically in skin loops) was blocked by cooling, the ventilatory response to histamine was abolished. We concluded that histamine stimulates breathing by stimulation of receptors whose afferent pathways are in the vagus nerves; the effective stimulus is not bronchoconstriction but is presumably due to direct stimulation of airway receptors.