SUPERFECUNDITY IN RATS TREATED WITH MARE GONADOTROPIC HORMONE
SUPERFECUNDITY IN RATS TREATED WITH MARE GONADOTROPIC HORMONE
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DOI：
10.1152/ajplegacy.1937.119.4.704
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发表时间：
1937-07-31
影响因子：
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通讯作者：
Cole, H. H.
中科院分区：
文献类型：
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作者：
Cole, H. H.
测定了母马促性腺激素对繁殖力的影响。 155 例在成熟动物中发生，288 例在未成熟动物中发生。仅在未成熟的动物中进行注射。导致超排卵并植入数量远远超过正常成熟[女性]的胎儿数量。成熟大鼠被注射amts。动情期、发情期和动情中期的范围为 3 至 24 个单位。通过在动情中期注射12个大鼠单位，平均产仔数和大产仔数的百分比增加；但没有一窝产仔超过对照动物中发现的最大产仔大小。过量剂量会降低成熟和未成熟大鼠的可育交配百分比。在第 22 天注射并在第 25 天交配的大鼠中，胎儿着床。在第 26 至 31 天注射的大鼠中，49% 交配。怀孕第10天至第12天的尸检显示，植入的胎儿[长划线]数量惊人，多达28个。此时处死的老鼠中，38%的胎儿超过20个。第17天处死的一只大鼠有26个外观正常的胎儿；另一位在21日产下了23个活胎。在一个相当小的系列中，最多的出生人数是 17 名年轻的孩子。
The effect of mare gonadotropic hormone on fecundity was detd. in 155 instances in mature animals and in 288 immature animals. Only in the immature animal did the injs. result in superovulation and in the implantation of a number of fetuses far exceeding that found in the normal mature [female]. Mature rats were injected with amts. ranging from 3 to 24 units in dioestrum, oestrus, and metoestrum. The average litter size and the % of large litters were increased by injecting 12 rat units in metoestrum; but no litter exceeded in size the largest found in control animals. Excessive doses reduced the % of fertile matings in both mature and immature rats. Implantation of fetuses occurred in rats injected on the 22d day and mated on the 25th day of age. Of rats injected on the 26th to 31st day of age 49% mated. Necropsy on the 10th to 12th day of pregnancy revealed an astonishing number of implanted fetuses[long dash]as many as 28. Of the rats sacrificed at this time, 38% had in excess of 20 fetuses. One rat sacrificed on the 17th day had 26 normal-appearing fetuses; and another on the 21st day had 23 living fetuses. In a rather small series the largest number born was 17 living young.