Cutting edge: Differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation
Cutting edge: Differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation
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DOI：
10.4049/jimmunol.175.8.4829
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发表时间：
2005-10-15
影响因子：
4.4
通讯作者：
Harty, JT
中科院分区：
文献类型：
--
作者：
Jabbari, A;Harty, JT
记忆T细胞不需要自体多肽/MHC(SpMHC)复合体就能在体内长期存活。然而，当记忆CD4T细胞暂时放置在缺乏这些低水平TCR刺激的环境中时，就会失去排斥皮肤移植的能力。目前尚不清楚spMHC是否会改变CD8T细胞对体内刺激的反应能力。在这里，我们展示了记忆CD8 T细胞在过继转移到TAP(-/-)(MHC I类缺陷)或野生型小鼠后，保持了对树突状细胞介导的刺激的反应能力。令人惊讶的是，在没有MHC I类的情况下，幼稚的CD8 T细胞无法进行内稳态增殖并在数量上受到侵蚀，它也保留了对树突状细胞介导的抗原的反应能力，或者在转移到小鼠体内至少1周后。这些发现表明，维持CD8 T细胞功能和体内平衡增殖对spMHC信号有不同的需求。
Memory T cells do not require self-peptide/MHC (spMHC) complexes to survive long term in vivo. However, memory CD4 T cells lose the ability to reject skin grafts when transiently placed in an environment in which these low-level TCR stimulations are absent. Whether or not spMHC alters the ability of CD8 T cells to respond to stimulation in vivo remains unknown. Here, we show that memory CD8 T cells retain the ability to respond to dendritic cell-mediated stimulation after adoptive transfer into either TAP(-/-) (MHC class I-deficient) or wild-type mice. Surprisingly, naive CD8 T cells, which fail to undergo homeostatic proliferation and erode in number in the absence of MHC class I, also retain the ability to respond to dendritic cell-mediated antigenic or at least 1 wk after transfer into mice. These findings suggest a differential requirement for spMHC signals for maintenance of CD8 T cell function and homeostatic proliferation.