The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus
The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus
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DOI：
10.1016/j.jneuroim.2010.07.014
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发表时间：
2010-10-08
影响因子：
3.3
通讯作者：
Mohammed, Azza K.
中科院分区：
文献类型：
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作者：
Mostafa, Gehan A.;Ibrahim, Dalia H.;Mohammed, Azza K.
神经精神系统性红斑狼疮（NPSLE）是狼疮最难诊断的表现之一。血清脑抗体的测量有助于NPSLE的早期诊断和管理之前，一个衰弱的疾病的发展。我们的目的是评估血清抗神经节苷脂M1抗体在预测NPSLE中的价值，与其他用于NPSLE常规实验室诊断的抗体进行比较。此外，我们是第一个研究这些抗体与狼疮患者认知功能之间关系的人。对30例8-16岁无NPSLE临床表现的狼疮患者和30例健康对照者进行了血清抗神经节苷脂M1、抗核糖体P蛋白和抗心磷脂抗体的测定。每月进行一次神经精神评估和认知功能评估，随访12个月。12例患者在随访期间出现神经精神症状。在这些患者中，83.3%、50%和16.7%的患者在NPSLE临床表现前的初始评估时分别为抗神经节苷脂M1、抗核糖体P和抗心磷脂抗体阳性。抗神经节苷脂血清阳性与认知功能障碍之间存在显著正相关（P
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most difficult manifestations of lupus to diagnose. Measurement of serum brain antibodies has contributed to early diagnosis and management of NPSLE before development of a debilitating disease. We aimed to assess the value of serum anti-ganglioside M1 antibodies in prediction of NPSLE, in comparison to other antibodies used in routine laboratory diagnosis of NPSLE. In addition, we are the first to study the relationship between these antibodies and cognitive function in lupus patients. Serum anti-ganglioside M1, anti-ribosomal P protein and anti-cardiolipin antibodies were measured in 30 lupus patients without clinical evidence of NPSLE, aged 8-16 years, and 30 healthy matched-subjects. Patients were followed-up clinically by monthly neuropsychiatric evaluation and assessment of cognitive function for 12 months. Twelve patients developed neuropsychiatric manifestations during followup. Of those patients, 83.3%, 50% and 16.7% were seropositive for anti-ganglioside M1, anti-ribosomal P and anti-cardiolipin antibodies, respectively at the time of initial evaluation before clinical presentation of NPSLE. There was a significant positive association between anti-ganglioside seropositivity and cognitive dysfunction (P