Association between Hyperacusis and Tinnitus
Association between Hyperacusis and Tinnitus
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DOI：
10.3390/jcm9082412
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发表时间：
2020-08-01
影响因子：
3.9
通讯作者：
Gallus, Silvano
中科院分区：
文献类型：
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作者：
Cederroth, Christopher R.;Lugo, Alessandra;Gallus, Silvano
许多耳鸣患者报告经历过听觉过敏（对声音的敏感性增强）。然而，缺乏对听觉过敏和耳鸣之间关系的估计。在这里，我们在瑞典的一项研究中调查了这种关系。共有3645名参与者（1984名耳鸣患者和1661名无耳鸣患者）通过LifeGene入组，LifeGene是一项来自瑞典普通人群的研究，年龄在18-90岁之间，并提供了有关社会人口统计学特征以及听觉过敏及其严重程度的信息。耳鸣的存在和严重程度是自我报告或使用耳鸣障碍量表（THI）进行评估。还比较了伴有（n= 1388）或不伴有（n= 1044）听觉过敏的耳鸣表型。在1661名无耳鸣的参与者中，1098名（66.1%）为女性，563名为男性（33.9%），平均（SD）年龄为45.1（12.9）。在1984名耳鸣患者中，1034名（52.1%）为女性，950名（47.9%）为男性，平均（SD）年龄为47.7（14.0）岁。听觉过敏与任何耳鸣[比值比（OR）3.51，95%置信区间（CI）2.99-4.13]、自我报告的重度耳鸣（OR 7.43，95% CI 5.06-10.9）和THI >= 58（OR 12.1，95% CI 7.06-20.6）相关。THI >= 58的相关性随着听觉过敏严重程度的增加而增加，中度和重度听觉过敏的OR分别为8.15（95% CI 4.68-14.2）和77.4（95% CI 35.0-171.3）。在听觉过敏和耳鸣之间的关联中，没有观察到性别差异。重度耳鸣中听觉过敏的发生率高达80%，表现出非常紧密的关系。在严重耳鸣的情况下，区分这两种情况之间的病理生理机制将是具有挑战性的，优化的研究设计是必要的，以更好地了解听觉过敏和耳鸣之间密切关系背后的机制。
Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18-90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n= 1388) or without (n= 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99-4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06-10.9), and THI >= 58 (OR 12.1, 95% CI 7.06-20.6). The association with THI >= 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68-14.2) for moderate and 77.4 (95% CI 35.0-171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.