Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification
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DOI：
10.1038/s41598-019-48641-z
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发表时间：
2019-08-20
影响因子：
4.6
通讯作者：
Parola, Stephane
中科院分区：
文献类型：
--
作者：
Halttunen, Niki;Lerouge, Frederic;Parola, Stephane
计算机断层扫描（CT）是一种广泛使用的成像方式。在最近为扩大检测范围以优化诊断而进行的技术改进中，双能 CT 等新设备允许进行元素区分，但仍然仅限于两种能量。能谱光子计数CT（SPCCT）是一种新兴的X射线成像技术，具有全新的多能量探测和高空间分辨率（200μm）。这种独特的技术可以对给定元素进行检测和定量，因为能量（K 波段）的 X 射线吸收随元素的原子序数而增加。迄今为止使用的主要造影剂是碘基化合物，但碘的 K 边缘 (33.2 keV) 超出了检测范围。因此，开发适合这项先进技术的造影剂至关重要。钆是众所周知的 MRI 元素，具有非常适合 SPCCT 模式的 K 边缘 (50.2 keV)。高局部浓度的必要性推动了使用纳米物体代替分子实体。在这项工作中，纳米 GdF3 在基于临床的原型上进行了验证，可用作有效的体内造影剂。除了极高的稳定性外，它在血池中的持续时间很长，可以对小动物进行灌注成像，而没有明显的毒性。
Computed tomography (CT) is a widely used imaging modality. Among the recent technical improvements to increase the range of detection for optimized diagnostic, new devices such as dual energy CT allow elemental discrimination but still remain limited to two energies. Spectral photon-counting CT (SPCCT) is an emerging X-ray imaging technology with a completely new multiple energy detection and high spatial resolution (200 mu m). This unique technique allows detection and quantification of a given element thanks to an element-specific increase in X-ray absorption for an energy (K-band) depending on its atomic number. The main contrast media used hitherto are iodine-based compounds but the K-edge of iodine (33.2 keV) is out of the range of detection. Therefore, it is crucial to develop contrast media suitable for this advanced technology. Gadolinium, well known and used element for MRI, possess a K-edge (50.2 keV) well suited for the SPCCT modality. The use of nano-objects instead of molecular entities is pushed by the necessity of high local concentration. In this work, nano-GdF3 is validated on a clinical based prototype, to be used as efficient in vivo contrast media. Beside an extremely high stability, it presents long lasting time in the blood pool allowing perfusion imaging of small animals, without apparent toxicity.