Reduced white matter integrity in attention-deficit hyperactivity disorder.
Reduced white matter integrity in attention-deficit hyperactivity disorder.
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DOI：
10.1097/wnr.0b013e3283174415
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发表时间：
2008-11-19
期刊：
影响因子：
1.7
通讯作者：
Narr KL
中科院分区：
文献类型：
--
作者：
Hamilton LS;Levitt JG;O'Neill J;Alger JR;Luders E;Phillips OR;Caplan R;Toga AW;McCracken J;Narr KL
我们使用弥散张量成像来研究注意力缺陷多动障碍（ADHD）的分数各向异性（FA），这是一种衡量纤维束完整性的指标。我们使用基于神经束的图谱方法对17名ADHD儿童和青少年以及16名年龄匹配的对照组的六向扩散张量成像数据进行了FA检查，包括扣带回、胼胝体、皮质脊髓束、穹窿、视放射、上级纵束、钩束以及上级和下枕额束。与对照组相比，ADHD患者皮质脊髓束（P=0.02）和上级纵束（P=0.017）的FA显著降低。结果支持运动和注意力网络的中断可能有助于ADHD的病理生理学。未来的研究可能会澄清ADHD亚型和精神病合并症如何影响扩散措施。
We used diffusion tensor imaging to investigate fractional anisotropy (FA), a measure of fiber tract integrity, in attention-deficit hyperactivity disorder (ADHD). Using a tract-based atlasing approach on six-direction diffusion tensor imaging data, we examined FA within the cingulum, corpus callosum, corticospinal tract, fornix, optic radiations, superior longitudinal fasciculus, uncinate fasciculus, and the superior and inferior occipitofrontal fasciculi in an all-male sample of17 children and adolescents with ADHD and 16 age-matched controls. ADHD patients had significantly lower FA in the corticospinal tract (P=0.02) and the superior longitudinal fasciculus (P=0.017) compared with controls. Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures.