Prognostic role of albumin level in heart failure: A systematic review and meta-analysis.
Prognostic role of albumin level in heart failure: A systematic review and meta-analysis.
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白蛋白水平在心力衰竭中的预后作用：一项系统综述和荟萃分析
DOI：
10.1097/md.0000000000024785
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发表时间：
2021-03-12
期刊：
影响因子：
1.6
通讯作者：
Refaat MM
中科院分区：
文献类型：
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作者：
El Iskandarani M;El Kurdi B;Murtaza G;Paul TK;Refaat MM
低白蛋白血症（HA）在HF中很常见，然而，其病理生理学和临床意义知之甚少。虽然在过去的十年中已经发表了多项研究，调查血清白蛋白在HF中的作用，但对于这种广泛可用的测量方法的预后价值仍然没有达成共识。本研究的目的是评估白蛋白在心力衰竭（HF）患者中的预后作用。对MEDLINE、EMBASE、科克伦数据库进行了非限制性检索。根据相关性和合格性标准对结果进行筛选。提取相关数据，采用综合Meta分析软件进行分析。Begg和Mazumdar等级相关检验用于评价发表偏倚。共分析了48项研究，检查了44，048例HF患者。在32%（95%置信区间[CI] 28.4%-37.4%）的HF患者中发现HA，具有显著异质性（I2 = 98%）。 在10项评价急性HF的研究中，HA患者的院内死亡率几乎高出4倍，比值比（OR）为3.77（95% CI 1.96-7.23）。HA还与长期死亡率显著增加相关（OR：1.5; 95% CI：1.36-1.64），尤其是出院后1年时（OR：2.44; 95% CI：2.05-2.91; I2 = 11%）。 在预测HF患者死亡率方面，合并曲线下面积（AUC0.73; 95%CI 0.67-0.78）与血清脑钠肽（BNP）相当。我们的研究结果表明，HA与显著较高的住院死亡率以及长期死亡率相关，其预测准确性与血清BNP报告的准确性相当。这些结果表明，血清白蛋白可能是有用的，在确定高危患者。
Hypoalbuminemia (HA) is common in HF, however, its pathophysiology and clinical implications are poorly understood. While multiple studies have been published in the past decade investigating the role of serum albumin in HF, there is still no consensus on the prognostic value of this widely available measure. The objective of this study is to assess the prognostic role of albumin in heart failure (HF) patient Unrestricted searches of MEDLINE, EMBASE, Cochrane databases were performed. The results were screened for relevance and eligibility criteria. Relevant data were extracted and analyzed using Comprehensive Meta-Analysis software. The Begg and Mazumdar rank correlation test was utilized to evaluate for publication bias. A total of 48 studies examining 44,048 patients with HF were analyzed. HA was found in 32% (95% confidence interval [CI] 28.4%–37.4%) HF patients with marked heterogeneity (I2 = 98%). In 10 studies evaluating acute HF, in-hospital mortality was almost 4 times more likely in HA with an odds ratios (OR) of 3.77 (95% CI 1.96–7.23). HA was also associated with a significant increase in long-term mortality (OR: 1.5; 95% CI: 1.36–1.64) especially at 1-year post-discharge (OR: 2.44; 95% CI: 2.05–2.91; I2 = 11%). Pooled area under the curve (AUC 0.73; 95% CI 0.67–0.78) was comparable to serum brain natriuretic peptide (BNP) in predicting mortality in HF patients. Our results suggest that HA is associated with significantly higher in-hospital mortality as well as long-term mortality with a predictive accuracy comparable to that reported for serum BNP. These findings suggest that serum albumin may be useful in determining high-risk patients.
DOI：
10.12659/msm.902786
发表时间：
2017-07-10
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
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作者：
Baydemir C;Ural D;Karaüzüm K;Balci S;Argan O;Karaüzüm I;Kozdağ G;Ağır AA
通讯作者：
Ağır AA
DOI：
10.1016/j.ehj.2017.02.003
发表时间：
2017-09
期刊：
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
影响因子：
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作者：
Abdellah AT;Mohamed AD;Hendawi HA;Omera MA
通讯作者：
Omera MA