Severe Vitamin D Deficiency in Human Immunodeficiency Virus-Infected Pregnant Women is Associated with Preterm Birth.
Severe Vitamin D Deficiency in Human Immunodeficiency Virus-Infected Pregnant Women is Associated with Preterm Birth.
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DOI：
10.1055/s-0036-1593536
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发表时间：
2017-04
影响因子：
2
通讯作者：
NISDI LILAC Protocol
中科院分区：
文献类型：
--
作者：
Jao J;Freimanis L;Mussi-Pinhata MM;Cohen RA;Monteiro JP;Cruz ML;Branch A;Sperling RS;Siberry GK;NISDI LILAC Protocol
Low maternal vitamin D has been associated with preterm birth (PTB). HIV-infected pregnant women are at risk for PTB, but data on maternal vitamin D and PTB in this population is scarce. In a cohort of Latin American HIV-infected pregnant women from the NICHD International Site Development Initiative (NISDI) protocol, we examined the association between maternal vitamin D status and PTB. Vitamin D status was defined as the following 25-hydroxyvitamin D levels: severe deficiency (<10 ng/mL), deficiency (10-20 ng/mL), insufficiency (21–29 ng/mL), and sufficiency (≥30 ng/mL). PTB was defined as delivery at <37 weeks gestational age (GA). Logistic regression was used to assess the association between maternal vitamin D status and PTB. Of 715 HIV-infected pregnant women, 13 (1.8%) were severely vitamin D deficient, 224 (31.3%) deficient, and 233 (32.6%) insufficient. Overall, 23.2% (166/715) of pregnancies resulted in PTB [median GA of PTBs =36 wks (interquartile range: 34-36)]. In multivariate analysis, severe vitamin D deficiency was associated with PTB [Odds Ratio=4.7, 95% Confidence Interval: 1.3-16.8)]. Severe maternal vitamin D deficiency is associated with PTB in HIV-infected Latin American pregnant women. Further studies are warranted to determine if vitamin D supplementation in HIV-infected women may impact PTB.
