Towards precise brain stimulation: Is electric field simulation related to neuromodulation?
Towards precise brain stimulation: Is electric field simulation related to neuromodulation?
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DOI：
10.1016/j.brs.2019.03.072
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发表时间：
2019-09-01
影响因子：
7.7
通讯作者：
Floeel, Agnes
中科院分区：
文献类型：
--
作者：
Antonenko, Dania;Thielscher, Axel;Floeel, Agnes
背景资料：最近关于经颅直流电刺激（tDCS）的神经和行为后果的研究强调了个体因素的影响，例如决定电流场分布的大脑解剖结构，因此可能会显著影响刺激效果。计算建模方法可能会大大提高我们对这些因素的理解，但基于模拟的tDCS诱导场和神经生理学结果之间的关联尚未研究。目的：为tDCS诱导的神经生理学结果和单独诱导电场之间的关系提供经验证据。我们在24名受试者的闭眼静息态功能性共振成像（rsfMRI）中应用tDCS，并评估了前后磁共振波谱（MRS）。我们的目的是量化15分钟的tDCS使用“经典”的左SM 1-右眶上区蒙太奇的感觉运动网络（SMN）的强度和γ-氨基丁酸（GABA）和谷氨酸浓度的影响，实施交叉平衡设计与三个刺激条件。额外的结构解剖MRI序列和记录的个别电极配置允许个人电场模拟的基础上，所有参与者的逼真的头部模型为两个conditions.Results：在神经生理水平上，我们观察到预期的GABA浓度降低和SMN强度增加，无论是在阳极和阴极相比，假tDCS，复制以前的结果。tDCS诱导的神经生理调制的幅度显着相关的模拟为基础的电场强度内的目标左中央前gyms.Conclusion：我们的研究结果证实了以前的报告tDCS诱导的神经生理调制和进一步推进的理解的潜在机制，通过提供第一个经验证据的协会的注入电场和神经调节作用。(C)2019爱思唯尔公司All rights reserved.
Background: Recent research on neural and behavioral consequences of transcranial direct current stimulation (tDCS) has highlighted the impact of individual factors, such as brain anatomy which determines current field distribution and may thus significantly impact stimulation effects. Computational modeling approaches may significantly advance our understanding of such factors, but the association of simulation-based tDCS-induced fields and neurophysiological outcomes has not been investigated.Objectives: To provide empirical evidence for the relationship between tDCS-induced neurophysiological outcomes and individually induced electric fields.Methods: We applied tDCS during eyes-closed resting-state functional resonance imaging (rsfMRI) and assessed pre-post magnetic resonance spectroscopy (MRS) in 24 participants. We aimed to quantify effects of 15-min tDCS using the "classical" left SM1-right supraorbital area montage on sensorimotor network (SMN) strength and gamma-aminobutyric acid (GABA) and glutamate concentrations, implementing a cross-over counterbalanced design with three stimulation conditions. Additional structural anatomical MRI sequences and recordings of individual electrode configurations allowed individual electric field simulations based on realistic head models of all participants for both conditions.Results: On a neurophysiological level, we observed the expected reduction of GABA concentrations and increase in SMN strength, both during anodal and cathodal compared to sham tDCS, replicating previous results. The magnitudes of neurophysiological modulations induced by tDCS were significantly associated with simulation-based electric field strengths within the targeted left precentral gyms.Conclusion: Our findings corroborate previous reports on tDCS-induced neurophysiological modulations and further advance the understanding of underlying mechanisms by providing first empirical evidence for the association of the injected electric field and neuromodulatory effects. (C) 2019 Elsevier Inc. All rights reserved.