EFFECTS OF MIS-SPECIFYING GENETIC-PARAMETERS IN LOD SCORE ANALYSIS
EFFECTS OF MIS-SPECIFYING GENETIC-PARAMETERS IN LOD SCORE ANALYSIS
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DOI：
10.2307/2531059
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发表时间：
1986-06-01
期刊：
影响因子：
1.9
通讯作者：
HOCHEZ, J
中科院分区：
文献类型：
--
作者：
CLERGETDARPOUX, F;BONAITIPELLIE, C;HOCHEZ, J
lod评分法被广泛用于检测连锁和估计疾病位点与标记位点之间的重组分数。这些参数（基因频率、外显率和显性程度）假定在每个位点都是已知的。这一条件在疾病发生地可能不满足。在本文中，我们评估了由于使用错误的参数而引起的误差。连锁试验的功率对显性程度敏感，对穿透程度敏感，但对基因频率不敏感。相反，重组分数的估计可能受到任何遗传参数误差的强烈影响。
The lod score method is widely used to test linkage and to estimate the recombination fraction between a disease locus and a marker locus. The parameters (gene frequency, penetrance, and degree of dominance) are assumed to be known at each locus. This condition may not be fulfilled at the disease locus. In this paper, we evaluate the errors due to the use of wrong parameters. The power of the linkage test is sensitive to the degree of dominance, and slightly to the penetrate, but not to the gene frequently. In contrast, the estimation of the recombination fraction may be strongly affected by an error on any genetic parameter.