In Vivo Evaluation of Cisplatin-loaded Superabsorbent Polymer Microspheres for Use in Chemoembolization of VX2 Liver Tumors
In Vivo Evaluation of Cisplatin-loaded Superabsorbent Polymer Microspheres for Use in Chemoembolization of VX2 Liver Tumors
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DOI：
10.1016/j.jvir.2011.10.024
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发表时间：
2012-03-01
影响因子：
2.9
通讯作者：
Tomiyama, Noriyuki
中科院分区：
文献类型：
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作者：
Maeda, Noboru;Osuga, Keigo;Tomiyama, Noriyuki
目的：探讨顺铂超吸收性聚合物（SAP）混悬液化疗栓塞在兔移植性肝VX 2肿瘤模型中的药代动力学和疗效。材料和方法：将VX 2肿瘤植入8只兔的肝左叶。用载顺铂或未载顺铂的SAP进行肝固有动脉栓塞。顺铂SAP组（n = 4），肝固有动脉内注射SAP（106-150 μ m）5 mg，SAP内载顺铂2.35mg，离子型造影剂碘克沙酸320 mgl/mL 0.5mL。对照组（肝动脉灌注[HAT] + SAP; n = 4），在推注等量顺铂后，注射5 mg SAP负载0.5 mL碘克沙酸。测量前24小时内血浆铂浓度的连续变化。在第1周随访时进行血液采样和组织病理学检查。磁共振（MR）图像被用来计算VX 2肿瘤的生长率。顺铂负荷SAP组在最初24小时内总的和游离的血浆铂平均浓度仍然较低，尽管没有统计学意义（P > 0.05）。载顺铂SAP组的平均肿瘤生长率显著低于对照组（20% vs 116%; P = 0.049）。肝组织学检查显示，凝固性坏死的非肿瘤肝实质中的两只兔子在顺铂装载SAP组，虽然没有死亡occurred.Conclusions：这些结果表明，化疗栓塞顺铂装载SAP是一种安全和耐受的治疗，更有效地抑制肿瘤的生长。
Purpose: To investigate the pharmacokinetics and efficacy of chemoembolization with a cisplatin-loaded superabsorbent polymer (SAP) suspension in a rabbit model with transplanted liver VX2 tumors.Materials and Methods: VX2 tumors were implanted into the left lobe of the liver in eight rabbits. Embolization of the proper hepatic artery was performed with cisplatin-loaded or unloaded SAP. In the cisplatin-loaded SAP group (n = 4), 5 mg of SAP (106-150 mu m) loading 2.35 mg of cisplatin and 0.5 mL of ionic contrast material (ioxaglic acid 320 mgl/mL) was injected into the proper hepatic artery. In the control group (hepatic arterial infusion [HAT] + SAP; n = 4), 5 mg of SAP loading 0.5 mL of ioxaglic acid alone was injected after a bolus infusion of an equivalent amount of cisplatin. Sequential change of the plasma platinum concentration within the first 24 hours was measured. Blood sampling and histopathologic examination were performed at I-week follow-up. Magnetic resonance (MR) images were used to calculate the growth rate of the VX2 tumor.Results: All animals underwent successful embolization. Both total and free plasma platinum mean concentrations within the first 24 hours remained lower in the cisplatin-loaded SAP group, although without statistical significance (P > .05). The mean tumor growth rate was significantly lower in the cisplatin-loaded SAP group than the control group (20% vs 116%; P = .049). Flistopathologic examination revealed coagulative necrosis to nontumorous liver parenchyma in two rabbits in the cisplatin-loaded SAP group; although no deaths occurred.Conclusions: These results suggested that chemoembolization with cisplatin-loaded SAP was a safe and tolerable treatment and was more effective in suppressing the tumor growth.