Heterogeneity of HIV-1 latent reservoirs.
Heterogeneity of HIV-1 latent reservoirs.
复制标题
HIV-1 潜伏病毒库的异质性
DOI：
10.1097/cm9.0000000000001085
复制
发表时间：
2020-12-05
影响因子：
6.1
通讯作者：
Deng, Kai
中科院分区：
文献类型：
--
作者：
Zhao, Jia-Cong;Deng, Kai
关键词：
Abstract Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).
