Does smoke from biomass fuel contribute to anemia in pregnant women in Nagpur, India? A cross-sectional study.
Does smoke from biomass fuel contribute to anemia in pregnant women in Nagpur, India? A cross-sectional study.
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DOI：
10.1371/journal.pone.0127890
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Hibberd PL
中科院分区：
文献类型：
--
作者：
Page CM;Patel A;Hibberd PL
在发展中国家，50%以上的孕妇患有贫血，并与母亲和儿童的不良后果有关。我们假设，暴露于生物质燃料产生的烟雾——在资源有限的环境中，生物质燃料广泛用于满足家庭能源需求——可能会加剧妊娠期贫血，这可能是全身性炎症的结果。评估暴露于生物质燃料（木材、秸秆、作物秸秆或粪便）而非清洁燃料（电力、液化石油气、天然气或沼气）产生的烟雾是否是妊娠期贫血的独立危险因素（按严重程度分类）。作为美国国立卫生研究院资助的孕产妇和新生儿健康登记研究的一部分，使用2011-2013年从印度那格浦尔农村妊娠队列（N = 12,782）收集的数据进行了二次分析。使用多项逻辑回归来估计生物质燃料与清洁燃料使用对妊娠期贫血的影响，控制产妇年龄、体重指数、教育水平、暴露于家庭烟草烟雾、胎次、测量血红蛋白的三个月以及产前铁和叶酸补充剂的接受情况。任何贫血（血红蛋白< 11 g/dl）的患病率在生物质燃料使用者中为93%，在清洁燃料使用者中为88%。中度至重度贫血（血红蛋白< 10 g/dl）分别发生在53%和40%的女性中。多项逻辑回归显示，在调整协变量后，生物质燃料与清洁燃料使用者相比，轻度妊娠贫血（血红蛋白10-11 g/dl； RRR = 1.38, 95% CI = 1.19-1.61）和中度至重度妊娠贫血（RRR = 1.79, 95% CI = 1.53-2.09）的相对风险更高。在我们的研究人群中，暴露于生物质烟雾与妊娠期轻度和中度至重度贫血的高风险相关，独立于协变量。ClinicalTrials.gov NCT 01073475
Anemia affects upwards of 50% of pregnant women in developing countries and is associated with adverse outcomes for mother and child. We hypothesized that exposure to smoke from biomass fuel – which is widely used for household energy needs in resource-limited settings – could exacerbate anemia in pregnancy, possibly as a result of systemic inflammation. To evaluate whether exposure to smoke from biomass fuel (wood, straw, crop residues, or dung) as opposed to clean fuel (electricity, liquefied petroleum gas, natural gas, or biogas) is an independent risk factor for anemia in pregnancy, classified by severity. A secondary analysis was performed using data collected from a rural pregnancy cohort (N = 12,782) in Nagpur, India in 2011-2013 as part of the NIH-funded Maternal and Newborn Health Registry Study. Multinomial logistic regression was used to estimate the effect of biomass fuel vs. clean fuel use on anemia in pregnancy, controlling for maternal age, body mass index, education level, exposure to household tobacco smoke, parity, trimester when hemoglobin was measured, and receipt of prenatal iron and folate supplements. The prevalence of any anemia (hemoglobin < 11 g/dl) was 93% in biomass fuel users and 88% in clean fuel users. Moderate-to-severe anemia (hemoglobin < 10 g/dl) occurred in 53% and 40% of the women, respectively. Multinomial logistic regression showed higher relative risks of mild anemia in pregnancy (hemoglobin 10-11 g/dl; RRR = 1.38, 95% CI = 1.19-1.61) and of moderate-to-severe anemia in pregnancy (RRR = 1.79, 95% CI = 1.53-2.09) in biomass fuel vs. clean fuel users, after adjusting for covariates. In our study population, exposure to biomass smoke was associated with higher risks of mild and moderate-to-severe anemia in pregnancy, independent of covariates. ClinicalTrials.gov NCT 01073475
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作者：
Goudar, Shivaprasad S.;Carlo, Waldemar A.;McClure, Elizabeth M.;Pasha, Omrana;Patel, Archana;Esamai, Fabian;Chomba, Elwyn;Garces, Ana;Althabe, Fernando;Kodkany, Bhalachandra;Sami, Neelofar;Derman, Richard J.;Hibberd, Patricia L.;Liechty, Edward A.;Krebs, Nancy F.;Hambidge, K. Michael;Buekens, Pierre;Moore, Janet;Wallace, Dennis;Jobe, Alan H.;Koso-Thomas, Marion;Wright, Linda L.;Goldenberg, Robert L.
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DOI：
10.1179/2049396712y.0000000013
发表时间：
2013-03-01
影响因子：
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DOI：
10.1111/j.1447-0756.2011.01679.x
发表时间：
2012-01-01
影响因子：
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作者：
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DOI：
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发表时间：
2013-09-01
影响因子：
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作者：
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通讯作者：
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