α-Tocopherol attenuates NFκB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior
α-Tocopherol attenuates NFκB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior
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DOI：
10.1016/j.jneuroim.2005.08.003
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Johnson, RW
中科院分区：
文献类型：
--
作者：
Godbout, JP;Berg, GM;Johnson, RW
本研究旨在确定α -生育酚是否通过NF κ b依赖机制促进脂多糖（LPS）诱导的疾病行为的恢复。在第一项研究中，每天3次腹腔注射a-生育酚（20毫克）可以改善由腹腔注射LPS引起的疾病行为的恢复。此外，α -生育酚预处理可减弱lps激活的NF κ B和促炎细胞因子的产生。此外，在LPS之前通过ICV注射NF κ B诱饵特异性抑制脑内NF κ B活性，可显著加速LPS诱导的疾病行为的恢复。综上所述，这些数据表明-生育酚通过NF κ b依赖性途径调节大脑中的疾病行为和炎症细胞因子的产生。(C) 2005 Elsevier B.V.版权所有
This study was conducted to determine if alpha-tocopherol facilitates recovery from lipopolysaccharide (LPS)-induced sickness behavior through a NF kappa B-dependent mechanism. In the first study, 3 daily intraperitoneal (i.p.) injections of a-tocopherol (20 mg) improved recovery from sickness behavior induced by i.p. injected LPS. Furthermore, alpha-tocopherol pretreatment attenuated LPS-activated NF kappa B and proinflammatory cytokine production in brain. In addition, inhibiting NF kappa B activity in the brain specifically by ICV injection of a NF kappa B decoy prior to LPS, significantly accelerated recovery from LPS-induced sickness behavior. Taken together, these data indicate alpha-tocopherol modulates sickness behavior and inflammatory cytokine production in the brain through an NF kappa B-dependent pathway. (C) 2005 Elsevier B.V. All rights reserved.