DIET AND RISK OF CLINICAL DIABETES IN WOMEN
DIET AND RISK OF CLINICAL DIABETES IN WOMEN
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DOI：
10.1093/ajcn/55.5.1018
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发表时间：
1992-05-01
影响因子：
7.1
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
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作者：
COLDITZ, GA;MANSON, JE;SPEIZER, FE
为了确定饮食与临床非胰岛素依赖型糖尿病风险的关系，我们分析了84360名美国女性的前瞻性队列数据。在6年的随访中，我们确定了702例明确的事件病例。由于体重指数（BMI）是糖尿病的一个强有力的危险因素，我们在BMI（kg/M2）< 29 kg/m2的女性中研究了脂肪（包括类型），纤维，蔗糖和其他饮食成分与糖尿病风险的关系。在控制了体重指数、先前的体重变化和酒精摄入量后，我们观察到能量、蛋白质、蔗糖、碳水化合物或纤维的摄入量与糖尿病风险之间没有关联。与能量调整摄入量最低的五分位数的女性相比，植物脂肪、钾、钙和镁的相对风险（趋势检验）分别为0.61（P趋势= 0.03）、0.62（P趋势= 0.008）、0.70（P趋势= 0.005）和0.68（P趋势= 0.02）。这些负相关在肥胖女性（BMI大于或等于29）中减弱。
To determine the relations of diet with risk of clinical noninsulin-dependent diabetes, we analyzed data from a prospective cohort of 84360 US women. During 6 y of follow-up we identified 702 definite incident cases. Because body mass index (BMI) is a powerful risk factor for diabetes, we examined the relations of fat (including type), fiber, sucrose, and other components of diet to risk of diabetes, among women with BMIs (in kg/M2) < 29 kg/m2. After controlling for body mass index, previous weight change, and alcohol intake, we observed no associations between intakes of energy, protein, sucrose, carbohydrate, or fiber and risk of diabetes. Compared with women in the lowest quintile of energy-adjusted intake, the relative risks (and tests for trend) for those in the highest quintile were 0.61 (P trend = 0.03) for vegetable fat, 0.62 (P trend = 0.008) for potassium, 0.70 (Ptrend = 0.005) for calcium, and 0.68 (Ptrend = 0.02) for magnesium. These inverse associations were attenuated among obese women (BMIs greater-than-or-equal-to 29).