The Inescapable Influence of Noncoding RNAs in Cancer.
The Inescapable Influence of Noncoding RNAs in Cancer.
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DOI：
10.1158/0008-5472.can-15-1989
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发表时间：
2015-12-15
期刊：
影响因子：
11.2
通讯作者：
Slack FJ
中科院分区：
文献类型：
--
作者：
Adams BD;Anastasiadou E;Esteller M;He L;Slack FJ
这份报告总结了2015年Keystone研讨会上关于“微小RNA和非编码RNA在癌症中的作用”的信息。在发现第一个microRNA(MiRNA)近20年后，人们逐渐阐明了非编码RNA在发育过程中的作用及其在癌症中的失调机制。令人兴奋的是，miRNAs已经开始进入临床，用于对抗丙型肝炎等疾病和各种形式的癌症。因此，在这次Keystone会议上，提出了新的发现，增强了我们关于小而长的非编码RNA如何控制发育时间和致癌过程的观点。反复出现的主题包括，1)miRNAs如何被核糖核蛋白(RNP)复合体差异处理、降解和调节，2)控制发育过程的特定miRNA遗传网络在被破坏时如何导致癌症疾病，3)可用于治疗性地传递RNA以对抗癌症等疾病的技术，以及4)长非编码RNA的作用机制的阐明，这是目前知之甚少的一类非编码RNA。在会议期间，会议的重点是展示未发表的发现，涵盖的主题的广度反映了非编码RNA在发育和癌症中的影响是多么不可避免。
This report summarizes information presented at the 2015 Keystone Symposium on “MicroRNAs and Noncoding RNAs in Cancer”. Nearly two decades after the discovery of the first microRNA (miRNA), the role of noncoding RNAs in developmental processes and the mechanisms behind their dysregulation in cancer has been steadily elucidated. Excitingly, miRNAs have begun making their way into the clinic to combat disease such a hepatitis C, and various forms of cancer. Therefore, at this Keystone meeting novel findings were presented that enhance our view on how small and long noncoding RNAs control developmental timing and oncogenic processes. Recurring themes included, 1) how miRNAs can be differentially processed, degraded, and regulated by ribonucleoprotein (RNP) complexes, 2) how particular miRNA genetic networks that control developmental process, when disrupted, can result in cancer disease, 3) the technologies available to therapeutically deliver RNA to combat diseases such as cancer, and 4) the elucidation of the mechanism of actions for long noncoding RNAs, currently a poorly understood class of noncoding RNA. During the meeting there was an emphasis on presenting unpublished findings, and the breadth of topics covered reflected how inescapable the influence of noncoding RNAs are in development and cancer.