Structure and mechanism in prokaryotic mechanosensitive channels
Structure and mechanism in prokaryotic mechanosensitive channels
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DOI：
10.1016/s0959-440x(03)00106-4
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发表时间：
2003-08-01
影响因子：
6.8
通讯作者：
Rees, DC
中科院分区：
文献类型：
--
作者：
Perozo, E;Rees, DC
机械敏感通道作为机电开关，具有感知脂质双分子层物理状态的能力。MscL和MscS的x射线晶体结构提供了一个独特的机会来识别与这些结构不相关通道的打开和关闭相关的蛋白质运动类型，同时提供了一个框架来解决由通道-脂质相互作用定义的张力感知机制。最近的功能、结构和动态数据为这些膜蛋白的门控分子基础提供了新的见解。
Mechanosensitive channels function as electromechanical switches with the capability to sense the physical state of lipid bilayers. The X-ray crystal structures of MscL and MscS offer a unique opportunity to identify the types of protein motions associated with the opening and closing of these structurally unrelated channels, while providing the framework to address a mechanism of tension sensing that is defined by channel-lipid interactions. Recent functional, structural and dynamic data offer fresh insights into the molecular basis of gating for these membrane proteins.