Health of children born to medical radiographers
Health of children born to medical radiographers
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DOI：
10.1136/oem.53.2.73
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发表时间：
1996-02-01
影响因子：
4.9
通讯作者：
Beral, V
中科院分区：
文献类型：
--
作者：
Roman, E;Doyle, P;Beral, V
目的-制定一个可靠的方法收集信息的生殖结果在职业环境中，并调查健康的儿童出生的医疗radiographers. Methods-研究人口包括6730名成员的放射技师学院谁是，在调查时;年龄在30到64岁之间，在学院的当前会员档案上，并且居住在英国。结果-所开发的邮政方法被证明是可靠的，约87%的问卷被收回。观察到的生殖事件的频率与其他研究的结果大致一致：在报告的9208例妊娠中，83%为活产，12%为流产（胎龄< 20周），1%为死产（胎龄大于或等于20周），1%为其他罕见的自发性不良事件（异位妊娠，枯萎的卵子和葡萄胎）。男性和女性报告的不良生殖事件的频率几乎没有差异，但男性放射技师报告的医疗终止较少，比例为3。1%和1 .男女分别为4%。在儿童中，主要先天畸形的总体风险（RR 1 . 0，95%CI 0。9-1 . 2）、染色体异常（RR 1 . 4，95%CI 0 . 8-2 . 3），和癌症（RR 1。2 95%CI 0 . 7-2 . 0)根据一般人口比率计算，这与预期相符。女性放射技师的子女中除唐氏综合征以外的染色体异常的边缘过度（RR 3 . 9，95%CI 1。3-9 . 0，基于五次观察），以及男性放射技师子女的癌症（RR 2 . 7，95%CI 0 . 9-6 .根据5项观察结果（5）。这些风险的基础上的数字是小的，调查结果应谨慎解释conclusions.Conclusions-the邮政方法开发获得有关生殖事件和儿童健康的信息被证明是可靠的男性，以及在妇女。总体而言，医疗放射技师的调查结果令人放心。然而，由于放射技师的长期剂量记录没有以可访问的形式常规保存，因此无法检查剂量-反应关系。
Objectives-To develop a reliable method for collecting information on reproductive outcome in an occupational setting; and to investigate the health of children born to medical radiographers.Methods-The study population comprised 6730 members of the College of Radiographers who were, at the time of survey; aged between 30 and 64 years, on the current membership file of the College, and were resident in Britain.Results-The postal method developed proved to be reliable, with around 87% of questionnaires being returned. The observed frequencies of reproductive events were broadly in line with findings from other studies: of the 9208 pregnancies reported, 83% were livebirths, 12% were miscarriages (gestational age < 20 weeks), 1% were stillbirths (gestational age greater than or equal to 20 weeks), and 1% were other rarer spontaneous adverse events (ectopic pregnancy, blighted ovum, and hydatidiform mole). There was little difference between men and women in the frequency of adverse reproductive events reported, with the exception that male radiographers reported fewer medical terminations, the proportions being 3 . 1% and 1 . 4% for women and men respectively. Among children, the overall risks of major congenital malformation (RR 1 . 0, 95%CI 0 . 9-1 . 2), chromosomal anomaly (RR 1 . 4, 95%CI 0 . 8-2 . 3), and cancer (RR 1 . 2 95%CI 0 . 7-2 . 0) were as expected based on general population rates. Borderline excesses of chromosomal anomalies other than Down's syndrome in the children of female radiographers (RR 3 . 9, 95%CI 1 . 3-9 . 0, based on five observations), and cancer in the children of male radiographers (RR 2 . 7, 95%CI 0 . 9-6 . 5, based on five observations) were noted. The numbers on which these risks are based are small and the findings should be interpreted cautiously.Conclusions-The postal methods developed for obtaining information about reproductive events and child health proved to be reliable in men, as well as in women. Overall, the findings for medical radiographers are reassuring. Dose-response relations could not, however, be examined as long term dose records of radiographers are not routinely kept in an accessible form.