SOLID AND CYSTIC ACINAR CELL TUMOR OF THE PANCREAS - A TUMOR IN YOUNG-WOMEN WITH FAVORABLE PROGNOSIS
SOLID AND CYSTIC ACINAR CELL TUMOR OF THE PANCREAS - A TUMOR IN YOUNG-WOMEN WITH FAVORABLE PROGNOSIS
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DOI：
10.1007/bf00430819
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
RUCKERT, K
中科院分区：
文献类型：
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作者：
KLOPPEL, G;MOROHOSHI, T;RUCKERT, K
介绍了五例独特胰腺肿瘤的临床病理特征。这些肿瘤仅发生在年轻女性和青春期女孩中，体积较大（2.5-10厘米），症状不典型，呈纤维包膜，无转移证据。组织学特征包括（1）具有单形细胞模式和细胞内PAS阳性小球的实性区域，以及（2）具有囊性坏死、出血和胆固醇肉芽肿的大变性病灶。一些肿瘤细胞α1-抗胰蛋白酶呈阳性。酶原样颗粒的超微结构显示表明肿瘤的腺泡起源。因此，我们提出术语“实性囊性腺泡细胞肿瘤”。这种肿瘤在某些方面类似于幼儿中所谓的胰母细胞瘤。另一方面，必须将其与具有腺泡结构和预后不良的腺泡细胞癌清楚地区分开来。这种病变不包括在 WHO 胰腺肿瘤分类中。
The clinico-pathological features of five cases with a distinctive pancreatic tumour are presented. The tumours, which occurred only in young women and an adolescent girl, were of large size (2.5–10 cm), had an uncharacteristic symptomatology and showed fibrous encapsulation with no evidence of metastases. The histological features include (1) solid areas with a monomorphic cell pattern and intracellular PAS positive globules, and (2) large foci of degeneration with cystic necroses, haemorrhages and cholesterol granulomas. Some tumour cells were positive for α1-antitrypsin. The ultrastructural demonstration of zymogen-like granules suggests an acinar origin for the tumours. We therefore propose the term solid and cystic acinar cell tumour. This tumour resembles the so called pancreatoblastomas in small children in some respects. It must be clearly distinguished, on the other hand, from acinar cell carcinoma with its acinic structures and poor prognosis. This lesion is not included in the WHO classification of pancreatic neoplasms.