Anti-idiotypic antibodies bear the internal image of a human tumor antigen.
Anti-idiotypic antibodies bear the internal image of a human tumor antigen.
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抗独特型抗体具有人类肿瘤抗原的内部图像。
DOI：
10.1126/science.3952496
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Koprowski,H
中科院分区：
文献类型：
--
作者：
Herlyn,D;Ross,AH;Koprowski,H
山羊独特型抗体（抗独特型抗体；Ab2）识别与BALB/c小鼠IgG2a单克隆抗体（Ab1）人胃癌结合位点相关的独特型，用于免疫BALB/c小鼠和家兔。小鼠免疫获得IgG1同型单克隆抗-抗独特型抗体（Ab3）。Ab3和Ab1对同一肿瘤抗原具有相同的结合特异性和相似的结合活性。Ab2对ab1样Ab3的诱导并不局限于小鼠，因为Ab3也可以在家兔中诱导。小鼠和家兔衍生的Ab3与Ab1结合相同的胃肠道癌症相关抗原。这些发现表明，Ab2诱导抗原特异性Ab3的形成，可能是因为它具有肿瘤相关抗原的内部图像。因此，这种Ab2可能具有调节癌症患者对肿瘤的免疫反应的潜力。
Goat antibodies to idiotypes (anti-idiotypic antibodies; Ab2) that recognize an idiotype associated with the combining site of a BALB/c mouse IgG2a monoclonal antibody (Ab1) to human gastric carcinoma were used to immunize BALB/c mice and rabbits. A monoclonal anti-anti-idiotypic antibody (Ab3) of IgG1 isotype was obtained after immunization of mice. The Ab3 and the Ab1 showed identical binding specificities and bound with similar avidities to the same tumor antigen. The induction of Ab1-like Ab3 by Ab2 was not restricted to mice, since Ab3 could also be induced in rabbits. Both the mouse- and the rabbit-derived Ab3 bound the same gastrointestinal cancer-associated antigen as Ab1. These findings indicate that Ab2 induced the formation of antigen-specific Ab3, probably because it bears the internal image of the tumor-associated antigen. This Ab2 may therefore have potential for modulating the immune response of cancer patients to their tumors.