Comparison of chemiluminescence and toluidine blue in the diagnosis of dysplasia in leukoplakia: a cross-sectional study
Comparison of chemiluminescence and toluidine blue in the diagnosis of dysplasia in leukoplakia: a cross-sectional study
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DOI：
10.1111/jicd.12141
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发表时间：
2016-05-01
影响因子：
--
通讯作者：
Krishna, Annaji Gopal
中科院分区：
文献类型：
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作者：
Chaudhry, Astha;Manjunath, Muniraju;Krishna, Annaji Gopal
目的：早期诊断和治疗口腔癌的潜在恶性阶段可以降低发病率，提高患者的生存率和生活质量。白斑是最常见的潜在恶性疾病。单纯的临床检查不能区分发育不良和非发育不良的白斑。化学发光和甲苯胺蓝是辅助常规检查，早期发现异常增生。本研究比较化学发光和甲苯胺蓝对白斑发育不良的诊断效果。方法：对100例白斑患者进行常规口腔检查、维兹利特化学发光检查和甲苯胺蓝试验，并经组织病理学证实为不典型增生。结果：化学发光的敏感性为84.84%，特异性为41.17%，阳性预测值为73.68%，阴性预测值为58.33%，准确性为70%。甲苯胺蓝分别为42.4%、88.23%、87.50%、44.11%和58%。结论：两种技术在白斑异常增生的诊断中都有辅助作用，但甲苯胺蓝在识别异常增生的严重程度上更有效，从而有效区分高风险和低风险病变。
Aims: The early diagnosis and treatment of oral cancer at a potentially-malignant stage would reduce morbidity and improve the survival rates and quality of life of patients. Leukoplakia is the most common potentially-malignant disorder. Clinical examination alone cannot differentiate between dysplastic and non-dysplastic leukoplakia. Chemiluminescence and toluidine blue are adjuncts to conventional examination for the early detection of dysplasia. The present study was conducted to compare the efficacies of chemiluminescence and toluidine blue for the diagnosis of dysplasia in leukoplakia.Methods: One hundred patients with leukoplakia were subjected to conventional oral examination, chemiluminescent examination with ViziLite and toluidine blue test, followed by histopathological confirmation of dysplasia.Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of chemiluminescence was 84.84%, 41.17%, 73.68%, 58.33%, and 70%, respectively. For toluidine blue it was 42.4%, 88.23%, 87.50%, 44.11%, and 58% respectively.Conclusions: Both the techniques have adjunctive utility in the diagnosis of dysplasia in leukoplakia, but toluidine blue was more effective in identifying the more severe grades of dysplasia, and thus it effectively discriminated high-risk from low-risk lesions.