EXPERIMENTAL CERVICAL SPONDYLOSIS IN THE MOUSE
EXPERIMENTAL CERVICAL SPONDYLOSIS IN THE MOUSE
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DOI：
10.1097/00007632-199110001-00008
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发表时间：
1991-10-01
期刊：
影响因子：
3
通讯作者：
ONO, K
中科院分区：
文献类型：
--
作者：
MIYAMOTO, S;YONENOBU, K;ONO, K
采用椎旁后肌离断、棘突沿着及棘上韧带、棘间韧带切除的方法，建立了小鼠颈椎病动物模型。这种手术干预引起的颈椎机械不稳定加速了椎间盘退变的过程，并且当持续6-12个月时，诱发了小鼠的颈椎病。该实验模型的颈椎间盘病理结果各不相同：软骨组织增生和纤维环裂隙、髓核收缩、椎间盘材料突出和骨赘形成。本实验模型的建立对颈椎病发病机制的生物化学和生物力学研究具有重要意义。
A reproducible experimental model of cervical spondylosis in mice was established by means of detachment of the posterior paravertebral muscles from the vertebrae and resection of the spinous processes along with the supraspinous and interspinous ligaments. Mechanical instability in the cervical spine elicited by this surgical intervention accelerated the process of intervertebral disc degeneration, and when extended over a 6-12-month period, induced cervical spondylosis in the mice. The pathologic findings in the cervical intervertebral discs of this experimental model varied: proliferation of cartilaginous tissue and fissures in the anulus fibrosus, shrinkage of the nucleus pulposus, herniation of disc material, and osteophyte formation. The availability of this experimental model should be valuable for biochemical and biomechanical understanding of the pathogenesis of cervical spondylosis.