The clinical potentials of endogenous neurosteroids.
The clinical potentials of endogenous neurosteroids.
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内源性神经类固醇的临床潜力。
DOI：
10.1358/dot.2002.38.7.820115
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发表时间：
2002
期刊：
影响因子：
1.8
通讯作者：
D. Reddy
中科院分区：
文献类型：
--
作者：
D. Reddy
压力增加血浆和大脑中神经类固醇别孕烯醇酮和别四氢脱氧皮质酮（THDOC）的浓度，这可能对大脑中的GABAA受体产生有效影响。阻断神经类固醇的形成可以防止应激的特定生化和行为效应，这表明这些效应依赖于GABA（A）受体活性神经类固醇的作用。最近的研究提供了一个更好的了解内源性神经甾体在正常神经元发育和脑疾病的病理生理学的作用。生理性神经类固醇波动对压力敏感的神经系统疾病（如癫痫、婴儿痉挛症）以及精神疾病（如精神分裂症、创伤后应激障碍和抑郁症）具有潜在影响。未来的研究可能会提供重要的新证据，不仅可以解释急性应激反应，而且还可以揭示慢性应激过程中神经类固醇机制的临床重要性。
Stress increases plasma and brain concentrations of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone (THDOC), which can have potent effects on GABAA receptors in the brain. Blockade of the formation of neurosteroids prevents specific biochemical and behavioral effects of stress, suggesting that those effects are dependent upon the actions of GABA(A)-receptor active neurosteroids. Recent investigations provide a better understanding of the role of endogenous neurosteroids in normal neuronal development and in the pathophysiology of brain disorders. Physiological neurosteroid fluctuations have potential implications for stress-sensitive neurological conditions such as epilepsy, infantile spasms, as well as psychiatric disorders such as schizophrenia, posttraumatic stress disorder and depression. Future studies may provide important new evidence that may not only explain acute actions of stress, but also reveal the clinical importance of neurosteroid mechanisms during chronic stress.