Nutrient Regulation: Conjugated Linoleic Acid's Inflammatory and Browning Properties in Adipose Tissue.
Nutrient Regulation: Conjugated Linoleic Acid's Inflammatory and Browning Properties in Adipose Tissue.
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DOI：
10.1146/annurev-nutr-071715-050924
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发表时间：
2016-07
影响因子：
8.9
通讯作者：
Wan Shen;M. McIntosh
中科院分区：
文献类型：
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作者：
Wan Shen;M. McIntosh
肥胖是美国最普遍的营养性疾病。因此，制定有效且安全的策略来管理超重至关重要。减少肥胖的一种潜在策略是食用仅含有异构体 cis-9、trans-11 和 trans-10、cis-12 或 trans-10、cis-12 的共轭亚油酸 (CLA) 补充剂。所提出的 CLA 抗肥胖机制包括调节 (a) 脂肪生成、(b) 脂质代谢、(c) 炎症、(d) 脂肪细胞凋亡、(e) 脂肪组织褐变或米色以及 (f) 能量代谢。然而，CLA 介导的身体脂肪减少反应的因果关系，特别是炎症、产热和能量代谢之间的联系尚不清楚。本综述探讨了 CLA 的抗肥胖特性是否是由于炎症信号传导所致，并考虑了 CLA 与白色和棕色脂肪组织的脂肪生成、脂肪分解、产热和褐变的联系。我们提出了一系列问题和研究来探究交感神经系统在介导 CLA 抗肥胖特性中的作用。
Obesity is the most widespread nutritional disease in the United States. Developing effective and safe strategies to manage excess body weight is therefore of paramount importance. One potential strategy to reduce obesity is to consume conjugated linoleic acid (CLA) supplements containing isomers cis-9, trans-11 and trans-10, cis-12, or trans-10, cis-12 alone. Proposed antiobesity mechanisms of CLA include regulation of (a) adipogenesis, (b) lipid metabolism, (c) inflammation, (d) adipocyte apoptosis, (e) browning or beiging of adipose tissue, and (f) energy metabolism. However, causality of CLA-mediated responses to body fat loss, particularly the linkage between inflammation, thermogenesis, and energy metabolism, is unclear. This review examines whether CLA's antiobesity properties are due to inflammatory signaling and considers CLA's linkage with lipogenesis, lipolysis, thermogenesis, and browning of white and brown adipose tissue. We propose a series of questions and studies to interrogate the role of the sympathetic nervous system in mediating CLA's antiobesity properties.