Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential.
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential.
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TspanC8家族四跨膜蛋白对ADAM10的调节及其治疗潜力
DOI：
10.3390/ijms22136707
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发表时间：
2021-06-23
影响因子：
5.6
通讯作者：
Tomlinson MG
中科院分区：
文献类型：
--
作者：
Harrison N;Koo CZ;Tomlinson MG
广泛表达的跨膜蛋白去整合素和金属蛋白酶10（ADAM 10）通过在称为胞外域脱落的过程中将胞外区从其膜蛋白底物上切割下来而发挥“分子生物学”的功能。已知ADAM 10具有超过100种底物，包括Notch、淀粉样前体蛋白、钙粘蛋白和生长因子，并且对健康很重要，并与癌症和阿尔茨海默氏症等疾病有关。四跨膜蛋白是膜蛋白的超家族，其与特定的伴侣蛋白相互作用以调节它们的细胞内运输、侧向移动性和在细胞表面的聚集。我们和其他人已经表明，ADAM 10与一个亚组的六个四跨膜蛋白相互作用，称为TspanC 8亚组，这是密切相关的蛋白质序列，包括Tspan 5，Tspan 10，Tspan 14，Tspan 15，Tspan 17和Tspan 33。最近的证据表明，不同的TspanC 8/ADAM 10复合物具有不同的底物，ADAM 10不应被视为单一的底物，而应被视为六种不同的TspanC 8/ADAM 10底物复合物。这篇综述讨论了已发表的证据，这“六个”的假设和治疗潜力，这提供了。
The ubiquitously expressed transmembrane protein a disintegrin and metalloproteinase 10 (ADAM10) functions as a “molecular scissor”, by cleaving the extracellular regions from its membrane protein substrates in a process termed ectodomain shedding. ADAM10 is known to have over 100 substrates including Notch, amyloid precursor protein, cadherins, and growth factors, and is important in health and implicated in diseases such as cancer and Alzheimer’s. The tetraspanins are a superfamily of membrane proteins that interact with specific partner proteins to regulate their intracellular trafficking, lateral mobility, and clustering at the cell surface. We and others have shown that ADAM10 interacts with a subgroup of six tetraspanins, termed the TspanC8 subgroup, which are closely related by protein sequence and comprise Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33. Recent evidence suggests that different TspanC8/ADAM10 complexes have distinct substrates and that ADAM10 should not be regarded as a single scissor, but as six different TspanC8/ADAM10 scissor complexes. This review discusses the published evidence for this “six scissor” hypothesis and the therapeutic potential this offers.
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TSPANC8四跨果素差异调节ADAM10底物，Notch活化和ADAM10膜隔室的裂解。
DOI：
10.1007/s00018-015-2111-z
发表时间：
2016-05
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
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DOI：
10.1161/atvbaha.120.314301
发表时间：
2020-09-01
影响因子：
8.7
作者：
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通讯作者：
Mangin, Pierre H.
影响因子：
4.8
作者：
Haining, Elizabeth J.;Yang, Jing;Tomlinson, Michael G.
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影响因子：
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