The nuclear matrix in pathology
The nuclear matrix in pathology
复制标题
病理学中的核基质
作者：
F. Bosman
摘要：长期以来，核结构的分子基础一直是一个争论的问题，而不是一个既定的事实。在过去的十年中，核矩阵的概念已经出现，这种核基础设施的分子基础虽然还不完整，但正在逐渐被阐明。在有关核结构的早期研究中，来自胶原病患者的自身抗体发挥了重要作用。该基质是提取膜、核酸和组蛋白后剩余的结构，由核纤层、核仁和纤维颗粒网络组成。核层由核纤层组成。核仁基质含有参与 rRNA 加工的蛋白质。纤维颗粒网络由核基质蛋白组成，已发现多种核基质蛋白。已经清楚的是，核基质不仅为核结构提供了结构基础，而且在调节核功能中发挥着作用。核纤层蛋白提供细胞骨架和核内部之间的机械连续性。在癌症中已经描述了核纤层蛋白表达的异常模式；然而，这些方法的特异性不足以用于组织病理学诊断。核仁大小和核仁蛋白的表达水平已被证明与增殖活性密切相关，这可能会重新激发人们对核仁组织区域作为癌症组织学诊断工具的兴趣。原纤维颗粒网络参与复制和转录的功能划分。已经描述了多种核基质蛋白，它们似乎在癌细胞中特异性表达。这些蛋白质表达的分析可能在癌症诊断中发挥重要作用。
Abstract For a long time the molecular basis of nuclear structure has been a matter of debate rather than an established fact. In the last decade the concept of the nuclear matrix has emerged, and the molecular basis of this nuclear infrastructure, although still incomplete, is gradually being unravelled. In early studies concerning the nuclear structure, autoantibodies derived from patients with collagen disease had a significant role. This matrix, the structure remaining after extraction of membranes, nucleic acids and histones, consists of the nuclear lamina, the nucleolus and a fibrillogranular network. The nuclear lamina is composed of the lamins. The nucleolar matrix contains the proteins involved in rRNA processing. The fibrillogranular network is composed of nuclear matrix proteins, a wide variety of which has been discovered. It has become clear that the nuclear matrix not only provides a structural basis for nuclear architecture but also plays a part in regulating nuclear function. Lamins provide mechanical continuity between cytoskeleton and nuclear interior. Aberrant patterns of lamin expression have been described in cancer; these are not sufficiently specific to be used in histopathological diagnosis, however. Nucleolar size and expression levels of nucleolar proteins have been shown to correlate well with proliferative activity, which may revitalize interest in nucleolar organizing regions as a tool in histological diagnosis of cancer. The fibrillogranular network is involved in functional compartmentalization of replication and transcription. A variety of nuclear matrix proteins has been described, which appear to be specifically expressed in cancer cells. Analysis of expression of these proteins might play a significant role in cancer diagnosis.
登录
查看更多内容
DOI：
--
发表时间：
1995-10
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
M. Derenzini;V. Sirri;D. Treré;R. Ochs
通讯作者：
M. Derenzini;V. Sirri;D. Treré;R. Ochs
DOI：
10.1016/s0074-7696(08)61228-0
发表时间：
1995
期刊：
International review of cytology
影响因子：
--
作者：
Ronald Berezney;M. Mortillaro;Hong Ma;Xiangyun Wei;J. Samarabandu
通讯作者：
Ronald Berezney;M. Mortillaro;Hong Ma;Xiangyun Wei;J. Samarabandu
核基质蛋白作为有丝分裂装置的结构和功能成分。
DOI：
10.1016/s0074-7696(08)62614-5
发表时间：
1995
期刊：
International review of cytology
影响因子：
--
作者：
He,D;Zeng,C;Brinkley,BR
通讯作者：
Brinkley,BR
系统性硬化症中自身抗原的分子结构和功能。
影响因子：
5
作者：
Lee,B;Craft,JE
通讯作者：
Craft,JE
DOI：
10.1016/s0022-5347(01)63615-2
发表时间：
1998-04
期刊：
The Journal of urology
影响因子：
--
作者：
Y. Lakshmanan;E. N. Subong;A. Partin
通讯作者：
Y. Lakshmanan;E. N. Subong;A. Partin