Development of a core outcome set for use in determining the overall success of gastroschisis treatment
Development of a core outcome set for use in determining the overall success of gastroschisis treatment
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DOI：
10.1186/s13063-016-1453-7
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发表时间：
2016-07-27
期刊：
影响因子：
2.5
通讯作者：
Knight, Marian
中科院分区：
文献类型：
--
作者：
Allin, Benjamin;Ross, Andrew;Knight, Marian
背景：胃裂病研究的质量受到结果测量报告存在显著异质性的限制（PloS One 10(1):e0116908, 2015）。在研究中使用核心结局集是解决这一问题的一种建议方法(Trials 13:103, 2012; clinin Rheumatol 33(9):1313-1322, 2014；卫生服务政策17(1):1-2,2012)。最终，标准化结果测量报告将提高研究质量，并转化为对患者护理的改善。方法/设计：通过系统评价确定候选结果测量方法。这些结果措施将成为在线三阶段德尔菲过程的起点，该过程将由三个专家小组并行进行。面板1为新生儿面板，面板2为非新生儿面板，面板3为新生儿面板。在第1轮中，专家将被要求根据他们认为这些措施在决定他们/他们的孩子/他们的病人胃裂治疗的整体成功的重要性，对先前确定的结果措施进行1-9分的评分。在第二轮中，专家们将收到同样的结果衡量指标清单，以及他们的小组在第一轮中如何对结果进行评分的图形表示。他们将被要求根据小组其他成员的看法对结果进行重新评分。在第3轮中，专家们将再次被要求对每个结果进行重新评分，但这一次他们将收到所有三个小组的分数分布的图形表示，他们在重新评分时应该考虑到这一点。在第三轮德尔菲程序之后，将邀请40名专家参加面对面的协商一致会议。为了在不同的小组之间取得平衡，我们将有目的地邀请参与者。将讨论德尔菲过程的结果，并对结果重新评分。结果测试中，有70%的与会者给他们打了7-9分和
Background: Gastroschisis research is limited in quality by the presence of significant heterogeneity in outcome measure reporting (PloS One 10(1):e0116908, 2015). Using core outcome sets in research is one proposed method for addressing this problem (Trials 13:103, 2012; Clin Rheumatol 33(9):1313-1322, 2014; Health Serv Res Policy 17(1): 1-2, 2012). Ultimately, standardising outcome measure reporting will improve research quality and translate into improvements in patient care.Methods/design: Candidate outcome measures have been identified through systematic reviews. These outcome measures will form the starting point for an online, three-phase Delphi process that will be carried out in parallel by three panels of experts. Panel 1 is a neonatal panel, panel 2 is a non-neonatal panel and panel 3 is a lay panel. In round 1, experts will be asked to score the previously identified outcome measures from 1-9 based on how important they think the measures are in determining the overall success of their/their child's/their patient's gastroschisis treatment.In round 2, experts will be presented with the same list of outcome measures and with graphical representations of how their panel scored that outcome in round 1. They will be asked to re-score the outcome measure taking into account how important other members of their panel felt it to be. In round 3, experts will again be asked to re-score each outcome measure, but this time they will receive a graphical representation of the distribution of scores from all three panels which they should take into account when re-scoring.Following round 3 of the Delphi process, 40 experts will be invited to attend a face-to-face consensus meeting. Participants will be invited in a purposive manner to obtain balance between the different panels. The results of the Delphi process will be discussed, and outcomes re-scored. Outcome measures where >70 % of the participants at the meeting scored them as 7-9 and