Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart-Protecting Musk Pill on IL-6 and TNF-Alpha.
Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart-Protecting Musk Pill on IL-6 and TNF-Alpha.
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DOI：
10.1155/2017/3217395
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hoppe R
中科院分区：
文献类型：
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作者：
Cen W;Chen Z;Gu N;Hoppe R
麝香保心丸(HMP)是一种临床上用于防治冠心病的中药。本研究观察了人参皂苷对急性心肌梗死大鼠血清白细胞介素6(IL-6)和肿瘤坏死因子-α(α)水平的影响，并观察了炎性细胞因子水平的变化与急性心肌梗死大鼠心室重构的关系。采用冠脉结扎法建立SD大鼠急性心肌梗死模型。急性心肌梗死大鼠IL-6和肿瘤坏死因子-α水平升高。灯盏细辛治疗可降低急性心肌梗死大鼠血清IL-6和肿瘤坏死因子-α水平。组织病理学和透射电子显微镜的结果也与生化结果基本一致。我们的研究结果表明，炎性细胞因子IL-6和肿瘤坏死因子-α可诱导大鼠急性心肌梗死后心脏重构，其机制可能是通过下调IL-6和肿瘤坏死因子-α的表达，进而抑制心肌细胞超微结构的改变，从而改善心功能，改善心室重构。
Heart-Protecting Musk Pill (HMP) is a Traditional Chinese Medicine (TCM) that has been used for the prevention and treatment of coronary heart disease in clinic. The current study investigated the effect of HMP on the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and observed the relationship between level changes of inflammatory cytokines and ventricular remodeling in rats with acute myocardial infarction (AMI). Animal models of AMI were made by coronary artery ligation in Sprague-Dawley (SD) rats. AMI rats showed increased levels of IL-6 and TNF-α. Treatment with HMP decreases IL-6 and TNF-α concentrations in rats with AMI. Histopathological and transmission electron microscopic findings were also essentially in agreement with biochemical findings. The results of our study revealed that inflammatory cytokines IL-6 and TNF-α induce cardiac remodeling in rats after AMI; HMP improves cardiac function and ameliorates ventricular remodeling by downregulating the expression of IL-6 and TNF-α and further suppressing the ultrastructural changes of myocardial cells.