Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human.
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human.
复制标题
皮肤疼痛和痛觉过敏程度的周围神经相关性：猴子神经事件与人类感觉判断的比较。
DOI：
10.1152/jn.1983.50.1.1
复制
发表时间：
1983
影响因子：
2.5
通讯作者：
Robinson,CJ
中科院分区：
文献类型：
--
作者：
LaMotte,RH;Thalhammer,JG;Robinson,CJ
6.来自对照实验的证据表明，在正常皮肤中的热痛的幅度缩放和热损伤后痛觉过敏发展后的幅度缩放的变化不太可能依赖于AMH伤害感受器、低阈值温度感受器或血流的区域变化的活性。7.这些实验的结果表明，在CMH伤害感受器的活动是一个主要的外周决定因素的热疼痛感觉在正常皮肤，也有助于痛觉过敏热损伤后的皮肤。如果正常皮肤中的热痛的幅度如数据所示被编码在CMH伤害感受器的平均脉冲放电中，那么相同的神经编码，至少如猴子的伤害感受器的反应中所揭示的那样，不能完全解释人类在轻度热损伤后痛觉变化的幅度。候选人之间的人类感觉和猴子的神经事件的某些不匹配的解释进行了讨论。
6. Evidence from control experiments indicated it was unlikely that the magnitude scaling of heat pain in normal skin and the changes in magnitude scaling following the development of hyperalgesia after heat injury depended on activity in AMH nociceptors, low-threshold thermoreceptors, or regional changes in blood flow. 7. The results of these experiments suggest that activity in CMH nociceptors is a major peripheral determinant of heat pain sensation in normal skin and also contributes to the hyperalgesia following heat injury to the skin. If the magnitude of heat pain in normal skin is coded in the mean impulse discharge of CMH nociceptors as the data suggest, then the same neural code, at least as revealed in the responses of nociceptors in the monkey, does not fully account for the magnitude of change in pain sensation in humans following mild heat injury. Candidate explanations for certain mismatches between human sensory and monkey neural events are discussed.