National Epidemiology of Mycoses Survey (NEMIS):: Variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units
National Epidemiology of Mycoses Survey (NEMIS):: Variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units
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DOI：
10.1086/520194
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发表时间：
1999-08-01
影响因子：
11.8
通讯作者：
Wenzel, RP
中科院分区：
文献类型：
--
作者：
Rangel-Frausto, MS;Wiblin, T;Wenzel, RP
念珠菌属是医院内血流感染的第四大常见原因，25%-50%发生在重症监护病房。在为期18个月的前瞻性研究期间，每天对每个参与机构的外科（SICU）或新生儿重症监护室（NICU）收治的所有患者进行随访，在6个中心的7个SICU收治的4，276例患者中，有42例因念珠菌属引起的医院内血流感染（9.8/1，000入院; 0.99/1，000患者日）。在六个NICU收治的2，847名婴儿中，有35名婴儿因念珠菌属而出现院内血流感染（12.3/1，000入院人数; 0.64/1，000患者日）。以下是SICU中最常见的引起血流感染的念珠菌属：白色念珠菌，48%;光滑念珠菌，24%;热带念珠菌，19%;近平滑念珠菌，7%;未另行说明的念珠菌属，2%。在新生儿重症监护室中的分布如下：C。白色念珠菌占63%;光滑型占6%; C类，近平滑，29%;其他，3%，患者中，30%-50%发生偶然粪便定植，23%的SICU患者发生偶然尿液定植，三分之一的SICU医护人员的手为念珠菌属阳性。
Candida species are the fourth most frequent cause of nosocomial bloodstream infections, and 25%-50% occur in critical care units. During an 18-month prospective study period, all patients admitted for greater than or equal to 72 hours to the surgical (SICUs) or neonatal intensive care units (NICUs) at each of the participant institutions were followed daily, Among 4,276 patients admitted to the seven SICUs in six centers, there were 42 nosocomial bloodstream infections due to Candida species (9.8/1,000 admissions; 0.99/1,000 patient-days). Of 2,847 babies admitted to the six NICUs, 35 acquired a nosocomial bloodstream infection due to Candida species (12.3/1,000 admissions; 0.64/1,000 patient-days). The following were the most commonly isolated Candida species causing bloodstream infections in the SICU: Candida albicans, 48%; Candida glabrata, 24%; Candida tropicalis, 19%; Candida parapsilosis, 7%; Candida species not otherwise specified, 2%. In the NICU the distribution was as follows: C. albicans, 63%; C. glabrata, 6%; C, parapsilosis, 29%; other, 3%, Of the patients, 30%-50% developed incidental stool colonization, 23% of SICU patients developed incidental urine colonization, and one-third of SICU health care workers' hands were positive for Candida species.