DELIVERY OF TFPI-2 USING ULTRASOUND WITH A MICROBUBBLE AGENT (SONOVUE) INHIBITS INTIMAL HYPERPLASIA AFTER BALLOON INJURY IN A RABBIT CAROTID ARTERY MODEL
DELIVERY OF TFPI-2 USING ULTRASOUND WITH A MICROBUBBLE AGENT (SONOVUE) INHIBITS INTIMAL HYPERPLASIA AFTER BALLOON INJURY IN A RABBIT CAROTID ARTERY MODEL
复制标题
在兔颈动脉模型中，使用超声波和微泡剂 (SonoVue) 输送 TFPI-2 可抑制球囊损伤后的内膜增生。
DOI：
10.1016/j.ultrasmedbio.2010.08.013
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发表时间：
2010-11-01
影响因子：
2.9
通讯作者：
Chen, Juan
中科院分区：
文献类型：
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作者：
Zhou, Jie;Wang, Yuxue;Chen, Juan
在这里，我们报告了一种新的、简单且有效的方法，通过使用超声波和微泡剂（SonoVue）将基因传递到球囊损伤的颈动脉以预防再狭窄。组织因子途径抑制剂-2 (TFPI-2) 已被证明可以抑制动脉粥样硬化血管损伤后内膜增生。将新西兰白兔分为4组，每组14只，分别为球囊损伤治疗对照组、基因载体对照组、不使用超声的TFPI-2基因递送和使用超声的TFPI-2基因递送。 4周后，超声检查下TFPI-2组损伤动脉新生内膜增殖明显低于对照组（p
Here we report a new, simple and efficient method by using ultrasound and a microbubble agent (SonoVue) for delivering a gene to balloon-injured carotid arteries for restenosis prophylaxis. The tissue factor pathway inhibitor-2 (TFPI-2) has been shown to inhibit the postinjury intimae hyperplasia in atherosclerotic vessels. New Zealand white rabbits were divided into 4 groups with 14 in each, a treatment control for balloon injury, a gene vehicle control, a gene delivery of TFPI-2 without using ultrasound and a gene delivery of TFPI-2 using ultrasound. After four weeks, the injured artery neointimal proliferation was significantly lower in the TFPI-2 group with ultrasound than the control groups (p