Neuropeptide Y effect on food intake in broiler and layer chicks
Neuropeptide Y effect on food intake in broiler and layer chicks
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DOI：
10.1016/j.cbpa.2011.04.008
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发表时间：
2011-08-01
影响因子：
2.3
通讯作者：
Hasegawa, Shin
中科院分区：
文献类型：
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作者：
Saneyasu, Takaolci;Honda, Kazuhisa;Hasegawa, Shin
肉鸡比蛋鸡吃更多的食物。在本研究中，我们研究了产氧肽神经肽Y （NPY）在肉鸡和蛋鸡（Gallus Gallus）采食量差异中的作用。首先，我们比较了这些菌株在1、2、4和8日龄时下丘脑NPY及其受体（Y1和Y5受体）的mRNA水平。2日龄后肉仔鸡日采食量显著高于蛋鸡。除8日龄外，肉鸡下丘脑NPY mRNA水平显著低于蛋鸡。此外，肉仔鸡2日龄和4日龄（Y1受体）和2日龄（Y5受体）NPY受体mRNA水平也显著低于蛋鸡。上述结果提示，下丘脑NPY及其受体表达的差异并不是肉鸡采食量增加的原因。为了比较NPY对肉仔鸡和蛋鸡的增氧效应，我们接下来研究了NPY集中管理对这些菌株采食量的影响。在2、4和8日龄时，集中施用NPY显著提高了这两个品系的采食量。研究结果表明，肉鸡采食量的增加并不伴随着NPY及其受体的过度表达。(C) 2011爱思唯尔公司版权所有。
Broiler chicks eat more food than layer chicks. In this study, we examined the involvement of orexigenic peptide neuropeptide Y (NPY) in the difference in food intake between broiler and layer chicks (Gallus gallus). First, we compared the hypothalamic mRNA levels of NPY and its receptors (Y1 and Y5 receptors) between these strains at 1, 2, 4, and 8 days of age. Daily food intake was significantly higher in broiler chicks than layer chicks after 2 days of age. However, the hypothalamic NPY mRNA level was significantly lower in broiler chicks than layer chicks except at 8 days of age. In addition, the mRNA levels of NPY receptors were also significantly lower in broiler chicks than layer chicks at 2 and 4 days of age (Y1 receptor) or 2 days of age (Y5 receptor). These results suggest that the differences in the expressions of hypothalamic NPY and its receptors do not cause the increase in food intake in broiler chicks. To compare the orexigenic effect of NPY between broiler and layer chicks, we next examined the effects of central administration of NPY on food intake in these strains. In both strains, central administration of NPY significantly increased food intake at 2,4 and 8 days of age. All our findings demonstrated that the increase in food intake in broiler chicks is not accompanied with the over-expression of NPY or its receptor. (C) 2011 Elsevier Inc. All rights reserved.