Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020
Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020
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DOI：
10.2807/1560-7917.es.2020.25.28.2001260
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发表时间：
2020-07-16
期刊：
影响因子：
19
通讯作者：
Zambon, Maria
中科院分区：
文献类型：
--
作者：
Harvala, Heli;Mehew, Jennifer;Zambon, Maria
分析了436名与COVID-19相容的病史个体的血浆血清学反应性，其中包括256名实验室确诊的SARS-CoV-2感染患者。超过99%的实验室确诊病例产生了可测量的抗体反应（254/256），88%的病例含有中和抗体（226/256）。抗体水平在诊断后3个月内下降，强调了恢复期血浆采集时间的重要性。结合抗体测量可以为选择具有高中和抗体水平的恢复期血浆供者提供信息。
Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.