Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli
Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli
复制标题
使用剪切粘弹性模量分析和模拟大鼠肝纤维化的流变行为
DOI：
10.1631/jzus.b1300121
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发表时间：
2014-04-01
影响因子：
5.1
通讯作者：
Chen, Si-ping
中科院分区：
文献类型：
--
作者：
Zhu, Ying;Zheng, Yi;Chen, Si-ping
肝纤维化的过程改变了肝组织的流变学特性。本研究从剪切粘弹性模量的角度对大鼠从F0到F4肝纤维化分期进行了表征和比较。本研究将Zener模型和Voigt模型两种粘弹性模型应用于流变仪试验的实验数据，然后对各个纤维化阶段的弹性和粘度值进行估计。结果表明，中度纤维化（≤F2）与肝脏粘弹性有良好的相关性。平均Zener弹性E1从（0.452±0.094）kPa （F0）增加到（1.311±0.717）kPa (F2)，平均Voigt弹性E从（0.618±0.089）kPa （F0）增加到（1.701±0.844）kPa （F2）。平均Zener粘度从（3.499±0.186）Pa·s （F0）增加到（4.947±1.811）Pa·s (F2)，平均Voigt粘度从（3.379±0.316）Pa·s （F0）增加到（4.625±1.296）Pa·s （F2）。与粘度相比，无论采用何种粘弹性模型，弹性在F1和F2阶段的变化都较小。因此，估计弹性比黏度更有效地区分F0到F2的纤维化阶段。
The process of liver fibrosis changes the rheological properties of liver tissue. This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli. Here two viscoelastic models, the Zener model and Voigt model, were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage. The results demonstrate that moderate fibrosis (≤F2) has a good correlation with liver viscoelasticity. The mean Zener elasticity E1 increases from (0.452±0.094) kPa (F0) to (1.311±0.717) kPa (F2), while the mean Voigt elasticity E increases from (0.618±0.089) kPa (F0) to (1.701±0.844) kPa (F2). The mean Zener viscosity increases from (3.499±0.186) Pa·s (F0) to (4.947±1.811) Pa·s (F2) and the mean Voigt viscosity increases from (3.379±0.316) Pa·s (F0) to (4.625±1.296) Pa·s (F2). Compared with viscosity, the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used. Therefore, the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.