Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs
Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs
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DOI：
10.1053/j.gastro.2006.02.026
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发表时间：
2006-05-01
期刊：
影响因子：
29.4
通讯作者：
Burrin, Douglas G.
中科院分区：
文献类型：
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作者：
Sangild, Per T.;Siggers, Richard H.;Burrin, Douglas G.
背景与目的：早产和配方奶喂养是与婴儿坏死性小肠结肠炎（NEC）相关的关键危险因素，但对易患该疾病的肠道状况知之甚少。因此，采用结构、功能和微生物学指标来研究早产儿自发性NEC发展的病因。方法：在妊娠期92%时剖宫产，在婴儿保温箱中饲养，每3 h饲喂婴儿配方奶粉或初乳（n = 120），直至1 ~ 2日龄收集组织。结果：57%饲喂配方奶的猪（26/46）和5%饲喂初乳的猪（2/38）出现NEC的临床和组织病理学征象(P
Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P