Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats.
Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats.
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R-( )-8-羟基-2-(二正丙氨基)四氢萘对清醒大鼠视前区产生的心血管作用。
DOI：
10.1016/s0014-2999(96)00626-7
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发表时间：
1996
影响因子：
5
通讯作者：
Alper,RH
中科院分区：
文献类型：
--
作者：
Szabó,A;Bowman,M;Braun,CJ;Alper,RH
本实验旨在验证前脑5-HT_（1A）受体激活引起心血管反应的假说。在清醒大鼠视前区微量注射选择性5-HT 1A受体激动剂R-（+）-8-羟基-2-（二正丙基氨基）四氢萘[（+）-8-OH-DPAT]，剂量为0.2-20 nmol时，可使血压和心率升高;较低剂量（0.002和0.02 nmol）无效。同时给予甲硫替平，一种非选择性5-HT受体拮抗剂，进入视前区衰减的反应。外周β受体拮抗剂索他洛尔可阻断（+）-8-OH-DPAT诱发的心动过速，而阿托品硝酸甲酯则不能阻断。（+）-8-OH-DPAT在麻醉大鼠也能引起心动过速，但不能引起高血压。这些结果表明，视前区或前脑邻近区域的5-HT 1A受体的激活产生：（1）与交感肾上腺激活一致的心率增加;（2）血压升高，这可能是交感兴奋的结果或继发于行为唤醒。
Experiments were designed to test the hypothesis that activation of forebrain 5-HT1Areceptors elicits cardiovascular responses. The microinjection of R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin [(+)-8-OH-DPAT], a selective 5-HT1Areceptor agonist, in the preoptic area of conscious rats increased blood pressure and heart rate at doses of 0.2–20 nmol; lower doses (0.002 and 0.02 nmol) were ineffective. The concomitant administration of methiothepin, a non-selective 5-HT receptor antagonist, into the preoptic area attenuated the responses. In addition, he tachycardia elicited by (+)-8-OH-DPAT was abolished by the peripheral β-adrenoceptor antagonist sotalol, but not by atropine methyl nitrate. Finally, the tachycardia, but not the hypertension, was also produced by (+)-8-OH-DPAT in urethane-anesthetized rats. These results suggest that activation of 5-HT1Areceptors in the preoptic area or an adjacent region of the forebrain produces: (1) an increase in heart rate consistent with sympathoadrenal activation; and (2) an increase in blood pressure which might be the result of sympathoexcitation or secondary to behavioral arousal.