In Vitro Susceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations
In Vitro Susceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations
复制标题
DOI：
10.1128/aac.04191-14
复制
发表时间：
2015-03-01
影响因子：
4.9
通讯作者：
Busha, Karen
中科院分区：
文献类型：
--
作者：
Li, Henry;Estabrook, Mark;Busha, Karen
阿维巴坦是一种广谱的β-内酰胺酶抑制剂，与头孢他啶、头孢他林或氨曲南一起对57株产各种分子类型的β-内酰胺酶的革兰氏阴性菌株进行了试验。大多数菌株对单独的β-内酰胺类药物不敏感。对于AmpC酶、超广谱β-内酰胺酶(ESBL)和产KPC肠杆菌或铜绿假单胞菌，阿维巴坦将头孢他啶、头孢他林或氨曲南的MIC降低2048倍，至
Avibactam, a broad-spectrum beta-lactamase inhibitor, was tested with ceftazidime, ceftaroline, or aztreonam against 57 well-characterized Gram-negative strains producing beta-lactamases from all molecular classes. Most strains were nonsusceptible to the beta-lactams alone. Against AmpC-, extended-spectrum beta-lactamase (ESBL)-, and KPC-producing Enterobacteriaceae or Pseudomonas aeruginosa, avibactam lowered ceftazidime, ceftaroline, or aztreonam MICs up to 2,048-fold, to