METHODOLOGIC CONSIDERATIONS IN MEASURING GLYCOSYLATED HEMOGLOBIN IN EPIDEMIOLOGIC STUDIES
METHODOLOGIC CONSIDERATIONS IN MEASURING GLYCOSYLATED HEMOGLOBIN IN EPIDEMIOLOGIC STUDIES
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DOI：
10.1016/0895-4356(88)90116-3
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发表时间：
1988-01-01
影响因子：
7.2
通讯作者：
SHRAGO, ES
中科院分区：
文献类型：
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作者：
MOSS, SE;KLEIN, R;SHRAGO, ES
使用多元线性回归根据未孵育值和血糖预测孵育糖化血红蛋白值。在威斯康星州南部的一个大的，地理上确定的糖尿病人群中，通过一次性微柱技术测量血红蛋白A1（HbA 1）。在研究期间，进行血液样品的孵育以去除前Alc。使用788例患者的数据进行多元线性回归，得出方程：孵育HbA 1 = 0.897（未孵育HbA 1）-0.00332（血糖）+0.388。通过将孵育HbA 1的计算值替换为以糖尿病视网膜病变为因变量的多项逻辑回归中的实际值，“验证”了该方程。替代对模型的影响很小。进一步的验证是从一个独立的糖尿病患者样本中获得的。孵育HbA 1的计算值平均比实际值低0.4%。
Multiple linear regression was used to predict an incubated glycosylated hemoglobin value from the unincubated value and blood glucose. Hemoglobin A1 (HbA1) was measured by a disposable microcolumn technique in a large, geographically defined population of diabetic persons in southern Wisconsin. During the study, incubation of blood samples to remove pre-Alc was implemented. Multiple linear regression using data from a group of 788 patients yielded the equation: incubated HbA1 = 0.897 (non-incubated HbA1)-0.00332 (blood glucose) + 0.388. This equation was "validated" by substituting the calculated value of incubated HbA1 for the actual value in a multinomial logistic regression with diabetic retinopathy as the dependent variable. Little change in the model resulted from the substitution. Further validation was obtained from an independent sample of diabetic persons. Calculated values of incubated HbA1 were an average of 0.4% lower than the actual values.