Changes in the incidence of amyotrophic lateral sclerosis in Wakayama, Japan
Changes in the incidence of amyotrophic lateral sclerosis in Wakayama, Japan
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DOI：
10.1080/14660820510030031
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Kondo, T
中科院分区：
文献类型：
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作者：
Kihira, T;Yoshida, S;Kondo, T
在20世纪60年代，和歌山县的小泽和小泽地区的肌萎缩侧索硬化症（ALS）发病率远高于世界其他地区。然而，据报告，在1980年至1993年期间，这些地区的发病率逐渐下降。为了确定发病率下降是否持续，我们进行了一项回顾性流行病学研究，并确定了和歌山县1998年至2002年ALS的平均年发病率。在此期间遇到的ALS病例数为134例（男性79例，女性55例）。和歌山县的总年平均发病率为2.50/10万（男性3.08，女性1.99）。近年来，和歌山县的小泽川和小泽地区的老年人比例急剧上升，本研究中ALS的年平均发病率为10.56例（男性14.14例，女性7.66例）。在1990年对日本人口的粗比率进行年龄和性别标准化时，预期值为5.24（男性7.34，女性3.18），低于我们上次调查的结果。2002年12月31日，和歌山县的患病率为11.31（男性14.40，女性8.53）。在小泽川和小泽地区，粗患病率为52.81（男性70.70，女性38.28）。这些结果表明，和歌山县ALS的发病率，特别是女性的发病率，与以前的报告相比，稳步下降。然而，在和歌山县，特别是在小泽川和小灶地区，ALS的发病率在男性中持续很高。某些环境因素和性别特异性可能与重点地区ALS发病率下降有关。
In the 1960s, the incidence of amyotrophic lateral sclerosis (ALS) in the Kozagawa and Koza areas in Wakayama prefecture was much higher than that in other areas of the world. However, between 1980 and 1993, a gradual decrease in the incidence of the disease in these areas was reported. To ascertain whether the decreased incidence has persisted, we conducted a retrospective epidemiological study, and determined the average annual incidence of ALS in Wakayama prefecture from 1998 to 2002. The number of ALS cases encountered during the period was 134 ( male 79, female 55). The crude average annual incidence in Wakayama prefecture in total was 2.50 ( male 3.08, female 1.99) per 100,000. In the Kozagawa and Koza areas in Wakayama prefecture, where the senility rate rapidly increased in recent years, the average annual incidence of ALS in the present research was 10.56 ( male 14.14, female 7.66). When the crude rate was standardized for both age and sex to the Japanese population in 1990, the expected value was 5.24 ( male 7.34, female 3.18), which was lower than that of our previous survey. The prevalence in Wakayama prefecture at 31 December 2002 was 11.31 ( male 14.40, female 8.53). In Kozagawa and Koza areas, the crude prevalence was 52.81 ( male 70.70, female 38.28). These results indicated that the incidence of ALS in Wakayama prefecture, especially for females, steadily decreased compared to that in previous reports. However, a high incidence of ALS persisted among males in Wakayama prefecture, especially in the Kozagawa and Koza areas. Some environmental factors and gender specificity may be related to the decreased incidence of ALS in focus areas.