2 CLASSES OF SINGLE-INPUT X-CELLS IN CAT LATERAL GENICULATE-NUCLEUS .1. RECEPTIVE-FIELD PROPERTIES AND CLASSIFICATION OF CELLS
2 CLASSES OF SINGLE-INPUT X-CELLS IN CAT LATERAL GENICULATE-NUCLEUS .1. RECEPTIVE-FIELD PROPERTIES AND CLASSIFICATION OF CELLS
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DOI：
10.1152/jn.1987.57.2.357
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发表时间：
1987-02-01
影响因子：
2.5
通讯作者：
MASTRONARDE, DN
中科院分区：
文献类型：
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作者：
MASTRONARDE, DN
用视觉刺激和同时记录它们在视网膜的神经节细胞输入的方法研究了猫的膝状体背外侧核(LGN)中的细胞。本文描述了LGN X细胞的感受野特性和一种新的分类系统，这些细胞似乎基本上只接受一种兴奋性视网膜输入。这些X细胞分为两个不同的类别。一类细胞(XS，Single)的视觉反应复制了视网膜X细胞反应的基本形式。另一类细胞(XL，滞后)的反应有两个显著特征：反应开始时，它们的放电滞后于XS细胞或神经节细胞40-80ms；当XS细胞或神经节细胞不放电时，它们异常放电。因此，对于闪光点，XL细胞在刺激开始后，在XS细胞或视网膜X细胞的初始瞬时放电高峰期间被抑制；XL细胞在刺激抵消后，在XS细胞或视网膜X细胞停止放电后，通常有异常的放电峰值。对于移动的视杆，XS细胞或视网膜X细胞的反应主要发生在视杆位于感受野中心时，而典型的XL细胞的反应大多发生在视杆离开感受野中心之后。分析了视觉反应中各特征的潜伏期。对于几个视觉反应潜伏期，其分布明显为双峰分布，从而客观地证明了两类细胞的存在。仅使用SPOT和BAR响应的潜伏期，这些单输入信元中超过90%可以被可靠地识别为属于这两种类型之一。其余的细胞(128个细胞中的7个)在某些方面但不是所有方面介于两类之间；因为它们有一些共同的属性，这些细胞被保存在一个单独的组中(XPL，部分滞后)。XS细胞和XL细胞的轴突均可从视皮层逆行激活。XS细胞的皮质潜伏期通常为0.7-2.0ms，而XL-细胞的皮质潜伏期则要长得多，通常为2.4-5.0ms。XL细胞以前可能没有被认为是一个单独的类别，因为具有如此长潜伏期的细胞在过去很少被记录到。大多数XS细胞对中央闪光点的反应比视网膜X细胞的反应更短暂，对大多数XL细胞的反应更持久。
Cells in the cat's dorsal lateral geniculate nucleus (LGN) were studied by presentation of visual stimuli and also by simultaneous recording of their ganglion cell inputs in the retina. This paper describes receptive-field properties and a new system of classification for LGN X-cells that appear to receive essentially only one excitatory retinal input. These X-cells were of two distinct classes. The visual responses of one class of cell (XS, single) replicated the basic form of the responses of a retinal X-cell. The other class of cell (XL, lagged) had responses with two remarkable features: their firing lagged 40-80 ms behind that of XS-cells or ganglion cells at response onset, and they fired anomalously at times when XS-cells or ganglion cells would not be firing. Thus, for a flashing spot, XL-cells were inhibited from firing after stimulus onset, during the time when XS-cells or retinal X-cells had an initial transient peak in firing; XL-cells generally had an anomalous peak in firing after stimulus offset, after XS-cells or retinal X-cells had stopped firing. For a moving bar, XS-cells or retinal X-cells responded primarily while the bar was in the receptive-field center, whereas most of a typical XL-cell's response occurred after the bar had left the receptive-field center. The latencies of various features in the visual responses were analyzed. For several visual response latencies, the distribution was clearly bimodal, thus objectively demonstrating the existence of two cell classes. Using only the latencies from spot and bar responses, over 90% of these single-input cells could be reliably identified as belonging to one of the two classes. The remaining cells (7 of 128) were intermediate between the two classes in some but not all respects; because they had some properties in common, these cells were kept in a separate group (XPL, partially lagged). The axons of both XS- and XL-cells could be antidromically activated from visual cortex. Cortical latencies were typically 0.7-2.0 ms for XS-cells but much longer, typically 2.4-5.0 ms, for XL-cells. It is possible that XL-cells have not previously been recognized as a separate class because cells with such long latencies have been recorded infrequently in the past. Responses to central flashing spots were more transient than those of retinal X-cells for most XS-cells and more sustained for most XL-cells.(ABSTRACT TRUNCATED AT 400 WORDS)