DNA-REPAIR IN THE FISSION YEAST, SCHIZOSACCHAROMYCES-POMBE
DNA-REPAIR IN THE FISSION YEAST, SCHIZOSACCHAROMYCES-POMBE
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DOI：
10.1016/0027-5107(91)90177-p
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发表时间：
1991-09-01
期刊：
影响因子：
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通讯作者：
MURRAY, JM
中科院分区：
文献类型：
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作者：
LEHMANN, AR;CARR, AM;MURRAY, JM
对UV和/或γ-辐射敏感的裂殖酵母裂殖酵母的突变体已被分配到23个互补组，其可被分配到三个表型组。我们已经克隆了相应于12个互补组的突变体中纠正缺陷的基因。切除修复途径中的三个基因与来自进化上遥远的芽殖酵母酿酒酵母的切除修复基因具有高度的序列保守性。相比之下，迄今为止已经表征的重组修复途径中的那些基因与任何先前表征的基因几乎没有同源性。
Mutants of the fission yeast Schizosaccharomyces pombe which are sensitive to UV and/or gamma-irradiation have been assigned to 23 complementation groups, which can be assigned to three phenotypic groups. We have cloned genes which correct the deficiency in mutants corresponding to 12 of the complementation groups. Three genes in the excision-repair pathway have a high degree of sequence conservation with excision-repair genes from the evolutionarily distant budding yeast Saccharomyces cerevisiae. In contrast, those genes in the recombination repair pathway which have been characterised so far, show little homology with any previously characterised genes.