HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion
HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion
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DOI：
10.1515/hsz-2012-0153
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发表时间：
2013-01-01
影响因子：
3.7
通讯作者：
Haeussinger, Dieter
中科院分区：
文献类型：
--
作者：
Donner, Markus G.;Topp, Stefan A.;Haeussinger, Dieter
我们研究了冷缺血-再灌注大鼠肝脏（I/R）中肝胆转运系统的下调以及血红蛋白-谷氨酰胺200（HbG 200）对药理学血红素氧合酶-1（HO-1）预诱导的影响。冷I/R使再灌注期胆汁流量从3.10 ± 0.10 ml/3 h降至0.54 ± 0.20 ml/3 h（p
We studied the downregulation of hepatobiliary transport systems and the effect of pharmacological heme oxygenase-1 (HO-1) preinduction by Hemoglobin-Glutamer 200 (HbG200) in cold ischemia-reperfused rat liver (I/R). Cold I/R reduced bile flow in the reperfusion period from 3.10 +/- 0.10 ml/3 h to 0.54 +/- 0.20 ml/3 h (p