Interaction of adenosine 5'-triphosphate with metal ions X-ray structure of ternary complexes containing Mg(II), Ca(II), Mn(II), Co(II), ATP and 2,2'-dipyridylamine.
Interaction of adenosine 5'-triphosphate with metal ions X-ray structure of ternary complexes containing Mg(II), Ca(II), Mn(II), Co(II), ATP and 2,2'-dipyridylamine.
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腺苷 5-三磷酸与金属离子的相互作用含 Mg(II)、Ca(II)、Mn(II)、Co(II)、ATP 和 2,2-联吡啶胺的三元配合物的 X 射线结构。
DOI：
10.1080/07391102.1983.10507470
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发表时间：
1983
影响因子：
4.4
通讯作者：
P. Zanazzi
中科院分区：
文献类型：
--
作者：
R. Cini;M. Sabat;Muttaiya Sundaralingam;M. C. Burla;A. Nunzi;G. Polidori;P. Zanazzi
测定了ATP的Mg ~（2+）、Ca ~（2+）、Mn ~（2+）和Co ~（2+）类质同象配合物的X射线结构。金属离子被两个ATP分子的α、β和γ磷酸基团包裹在六配位中，从而阻断金属离子与腺嘌呤碱基的相互作用。第二种完全水合的金属离子M（H2O）2+（6）与ATP的γ磷酸基团形成强氢键，这表明在磷酰基转移反应中促进β和γ磷酸之间裂解的可能步骤。
The X-ray structures of the isomorphous Mg2+, Ca2+, Mn2+ and Co2+ complexes of ATP have been determined. The metal ions are wrapped in hexa-coordination by the alpha, beta and gamma phosphate groups of two ATP molecules thus blocking the interaction of the metal ions with the adenine base. A second metal ion which is fully hydrated, M(H2O)2+(6), is engaged in a strong hydrogen bond with the gamma phosphate group of ATP and suggests a possible step in facilitating the cleavage between the beta and gamma phosphates in phosphoryl transfer reactions.