Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage
Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage
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DOI：
10.1023/a:1021985030331
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发表时间：
1997-10-01
影响因子：
4.4
通讯作者：
Takaku, A
中科院分区：
文献类型：
--
作者：
Hirashima, Y;Nakamura, S;Takaku, A
本研究的目的是检查蛛网膜下腔出血（SAH）患者颈内静脉（而非外周静脉）血液中炎症和凝血因子的变化。结果显示，白细胞介素 6 (IL-6) 和血小板活化因子 (PAF) 浓度在 SAH 后的前 4 天内增加，并在长达 14 天的时间内保持升高状态，而白细胞介素 1 β (IL-1 β) 在 SAH 后 5-9 天内出现短暂增加，而肿瘤坏死因子 α (TNF-α) 保持不变。 SAH 后 5-9 天内不同的凝血因子也有所增加。此外，迟发性缺血性神经功能缺损 (DIND) 患者的 PAF 和凝血因子、冯维勒布兰德因子 (vWF) 和凝血酶-抗凝血酶 III 复合物 (TAT) 水平最高。这些结果表明，SAH 后 PAF 和其他炎症细胞因子的升高可能会导致与脑血管痉挛相关的高凝状态，而颈内静脉可能是更适合采集血液以检查这些因素的血管。
The aim of the present study was to examine the changes of inflammatory and coagulation factors in blood of the internal jugular vein, not of peripheral vein, in patients with subarachnoid hemorrhage (SAH). The results show that while interleukin-6 (IL-6) and platelet activating factor (PAF) concentrations increased within first 4 days after SAH and remained elevated up to 14 days, interleukin-1 beta (IL-1 beta) showed a transient increase between 5-9 days after SAH and tumor necrosis factor-alpha (TNF-alpha) remained unchanged. Also different coagulation factors were increased between 5-9 days after SAH. Moreover, patients with delayed ischemic neurological deficits (DIND) displayed the highest levels of PAF and the coagulation factors, von Willebrand factor (vWF) and thrombin-antithrombin III complex (TAT). These results suggest that elevation of PAF and other inflammatory cytokines following SAH may cause the hypercoagulation state that is associated with cerebral vasospasm and internal jugular vein may be more adequate vessel for sampling blood to examine these factors.