Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine
Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine
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DOI：
10.1016/j.bone.2017.12.012
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发表时间：
2018-03-01
期刊：
影响因子：
4.1
通讯作者：
Nakano, Takayoshi
中科院分区：
文献类型：
--
作者：
Ishimoto, Takuya;Yamada, Katsuhisa;Nakano, Takayoshi
健康的骨小梁显示出高度各向异性的骨小梁结构和骨小梁内胶原和磷灰石的优先取向，两者都主要沿沿着头尾轴定向。这使得松质骨在主要载荷方向（头尾轴）上变硬。然而，这些各向异性小梁特征的变化后，植入装置插入仍然不清楚。我们将骨小梁结构的各向异性和胶原和磷灰石的优先取向定义为骨小梁健康的参数。在本研究中，我们分析了两种类型的椎间融合器（开放式和封闭式箱式融合器）植入绵羊脊柱2个月和4个月后的这些参数。融合器周围和内部小梁健康的变化和演变取决于融合器类型和植入持续时间。在边界区域，封闭型融合器的骨小梁结构各向异性和磷灰石取向的值与各向同性条件下的值相似。相比之下，发现开放式椎间融合器的各向异性显著更大，表明开放式椎间融合器倾向于保持小梁各向异性。在开放式椎间融合器内，骨小梁结构各向异性和磷灰石取向在植入后随时间显著增加。评估骨小梁的各向异性可能有助于评估骨小梁的健康状况以及植入物设计的验证和改进。(C)2017作者（S）爱思唯尔公司出版这是CC BY许可下的开放获取文章。
Healthy trabecular bone shows highly anisotropic trabecular architecture and the preferential orientation of collagen and apatite inside a trabecula, both of which are predominantly directed along the cephalocaudal axis. This makes trabecular bone stiff in the principally loaded direction (cephalocaudal axis). However, changes in these anisotropic trabecular characteristics after the insertion of implant devices remain unclear. We defined the trabecular architectural anisotropy and the preferential orientation of collagen and apatite as parameters of trabecular bone health. In the present study, we analyzed these parameters after the implantation of two types of intervertebral fusion cages, open and closed box-type cages, into sheep spines for 2 and 4 months. Alteration and evolution of trabecular health around and inside the cages depended on the cage type and implantation duration. At the boundary region, the values of trabecular architectural anisotropy and apatite orientation for the closed-type cages were similar to those for isotropic conditions. In contrast, significantly larger anisotropy was found for open-type cages, indicating that the open-type cage tended to maintain trabecular anisotropy. Inside the open-type cage, trabecular architectural anisotropy and apatite orientation significantly increased with time after implantation. Assessing trabecular anisotropy might be useful for the evaluation of trabecular health and the validation and refinement of implant designs. (C) 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license.