Interferons and Interferon Inactivators in Aids, Arc and in Cancer Patients
Interferons and Interferon Inactivators in Aids, Arc and in Cancer Patients
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艾滋病、电弧和癌症患者中的干扰素和干扰素灭活剂
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
M. G. Ikossi
中科院分区：
文献类型：
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作者：
K. Chadha;J. Ambrus;M. G. Ikossi
越来越明显的是，干扰素系统的各种参数以及前列腺素和环核苷酸水平的变化在健康期间以及任何疾病过程的发作、进展和最终结果期间具有明确的作用。尽管人们对干扰素可能的临床应用越来越兴奋，但对不同个体干扰素产生能力的变化和变异来源知之甚少。人类干扰素的异质性现已在早期工作 (1) 以及基于 DNA 重组技术的最新工作 (2-4) 中得到充分证明。然而，这种异质性的临床意义尚不清楚。目前用于治疗任何类型感染的克隆干扰素是单个基因的产物。不同干扰素基因的表达很可能在不同类型的感染和恶性肿瘤中存在很大差异。如果是这种情况，可能需要针对每种类型的感染使用定制的干扰素制剂。这种方法似乎最多还需要几年的时间。鉴于缺乏这样的知识，似乎应该认真尝试更好地了解感染过程中宿主自身的干扰素系统以及操纵其以获得最大利益的方式方法。本文在这个方向上做了一些尝试。
It is becoming increasingly evident that changes in various parameters of the interferon system and in the levels of prostaglandins and cyclic nucleotides have a definite role during the health and during the onset, progression and the final outcome of any disease process. In spite of ever increasing excitement over the possible clinical application of interferons, very little is known about the changes and sources of variations in the interferon production capabilities of different individuals. Heterogeneity of human interferons is now well document from the earlier work (1) as well as from more recent work based upon DNA recombinant technology (2–4). However, the clinical significance of such a heterogeneity is not known. Cloned interferons used at present in the treatment of any type of infections are a product of a single gene. It is quite possible that expression of different interferon genes varies considerably in different types of infections and malignancies. If that is the case, it may be necessary to use a custom-tailored interferon preparation for each type of infection. Such an approach at best appears to be several years away. In view of lack of such a knowledge, it seems appropriate that serious attempts should be made towards better understanding of the host’s own interferon system during infection and ways and means of its manipulation for maximal benefit. In this text, some attempts have been made in this direction.